.To the best of our knowledge, this is the first family with multiple AIS patients harboring homozygous MTHFR gene C677T (G80A-RFC1) mutations without associated hyperhomocysteinemia (the latter factor is usually considered as effector of vascular damage in patients with MTHFR C677T mutations)....
Homozygous MTHFR C677T carriers develop idiopathic portal vein thrombosis 20 years earlier than wild typedoi:10.1097/MBC.0000000000001299homocysteineidiopathic portal vein thrombosismethylenetetrahydrofolate reductaseprotein CThe aim of this study was to evaluate the impact of methylene tetrahydrofolate ...
Patients with the MTHFR C677T homozygous polymorphism had 1.889 times higher odds of having endometriosis diagnosis than patients without the MTHFR C677T homozygous polymorphism. 3. Discussion This study showed that, after controlling for confounders, an MTHFR C677T homozygous polymorphism might be con...
I had 2 miscarriages before I was tested for mthfr and I am homozygous c677t. I had to do injections of heparin, a blood thinner, in my abdomen 2x a day while pregnant. Now I have 2 beautiful children! Reply Kasey October 20, 2016 at 12:29 AM I had a child born with a nue...
Further, homozygous polymorphic TT genotype for the MTHFR C677T polymorphism is the only hereditary risk factor that has been identified to be associated with increased blood pressure [8]. Although, there are many studies in the literature that investigated the association between variants of MTHFR ...
The T allele was significantly more prevalent among patients compared with controls ([OR] 2.517; (P = 0.001)) (Fig. 1). For the A1298C, evaluations revealed that the AA homozygous genotype was lower in patients (11%) than in the control group (45.3%). The AC heterozygous genotype...
Our previous data showed the existence of a gene-environment interaction between the MTHFR 677 C→T and folate status not only in TT homozygous mutants but also in CT heterozygous subjects (12). Such observations prompted us to study a larger sample of subjects with the following aims: 1) ...
However, the serum levels of vitamin B2 and B12 and the MTHFR C677T genotypes interact in ways which has a different effect on the EPL and ESCC risks. For the homozygous wild genotype CC subjects who have normal activity of MTHFR, high serum levels of vitamin B2 and B12 were significantly...
Factor VL G1691A and MTHFR C677T genotypes were determined by RT PCR. Results The prevalence of heterozygous FVL GA genotype was significantly higher among MI patients as compared to the control group. The prevalence of mutant homozygous AA was significantly higher in MI patients as compared to...
Silva et al., only confirms the association between increased plasma homocysteine concentration in Alzheimer's disease and suggests that C677T MTHFR polymorphisms not contributed to genetic susceptibility for Alzheimer's disease in elderly individuals in the Northeast of Brazil [28]....