However, the serum levels of vitamin B2 and B12 and the MTHFR C677T genotypes interact in ways which has a different effect on the EPL and ESCC risks. For the homozygous wild genotype CC subjects who have normal activity of MTHFR, high serum levels of vitamin B2 and B12 were significantly...
.To the best of our knowledge, this is the first family with multiple AIS patients harboring homozygous MTHFR gene C677T (G80A-RFC1) mutations without associated hyperhomocysteinemia (the latter factor is usually considered as effector of vascular damage in patients with MTHFR C677T mutations)....
The MTHFR C677T (rs1801133) polymorphism is a missense mutation that causes the substitution of alanine to valine in 222th and 263th positions of the amino acid sequence of methylenetetrahydrofolate reductase (NADPH) which results in functional loss [1]. Homozygous TT genotype carriers for the ...
Disease risk was found 2.27-folds increased in patients who were carrying T allele. We found an association of C677T polymorphism with male infertility and that it may be a genetic risk factor for male infertility in North Indian population. This is a preview of subscription content, log in ...
Patients with the MTHFR C677T homozygous polymorphism had 1.889 times higher odds of having endometriosis diagnosis than patients without the MTHFR C677T homozygous polymorphism. 3. Discussion This study showed that, after controlling for confounders, an MTHFR C677T homozygous polymorphism might be con...
Homozygous for C677T have an estimated 70% loss of function Heterozygous for C677T have an estimated 40% loss of function There is a lot of debate about whether those with the A1298C mutation experience diminished function. Some say no, but based on what I’ve read of Dr. Lynch’s wo...
An association of homozygous MTHFR 677T genotypes with elevated plasma homocysteine level has been documented, but results are still controversial. We aimed to investigate prevalence of the C677T polymorphism in patients with acute myocardial infarction (MI) in the Eastern Black Sea region of Turkey...
ObjectiveTo explore the role of clinical pharmacist in individualized treatment of hypertension.MethodsA patient with "H" hypertension receiving pharmaceutical care from clinical pharmacists was retrospectively analyzed.ResultsPatient's MTHFR (C677T) gene type was TT homozygous. Clinical pharmacist suggested...
did not find association with polymorphisms of MTHFR in the outcome of pegylated-IFNα plus ribavirin treatment in patients with chronic hepatitis C, only the homocysteine levels [27]. Silva et al., only confirms the association between increased plasma homocysteine concentration in Alzheimer's ...
The CT and TT genotypes of the C677T gene polymorphism exhibited substantial risks for having stroke disease [(OR 3.856; P ≤ 0.001); (OR 4.026; P ≤ 0.001), respectively]. The T allele was significantly more prevalent among patients compared to controls. (OR 2.517; (P = ...