The prevalence of the mutated homozygous and heterozygous C677T MTHFR genotype in the patients with arterial stroke was 1.4% (one of 69) and 31.88% (21 of 69), respectively. There frequency was 16.6% (one of six) and 33.3% (two of six) in venous stroke. The genotyping results from ...
A common mutation (C677T), which results in high homocysteine and low plasma folate levels, has been associated with a thermolabile form of the MTHFR enzyme, therefore being a risk factor for cardiovascular diseases and neural tube defects (NTD) in the homozygous form (Frosst, 1995). Another...
We found that both the heterozygous CT (adjusted OR = 0.78, 95% CI: 0.67–0.92) and the homozygous TT genotypes (adjusted OR = 0.68, 95% CI: 0.55–0.83) of c.677C>T were associated with a significantly decreased risk of PCa compared with homozygous wild-type CC genotype, ...
C677Tsite,respectively.After hybridizationwithamplifiedDNAfragment,thehybridsweredetectedwithacolorimetricm ethodandthegenotypewere identifiedbycalculatingtheratioofabsorbentobtainedwithtWOprobes.Results:Thepolym orphismof50sampleswere analysedbythemethod.Wildtype,heterozygousandhomozygousweredetectedin15cases, 28cases...
The MTHFR C677T (rs1801133) polymorphism is a missense mutation that causes the substitution of alanine to valine in 222th and 2 63th positions of the amino acid sequence of methylenetetrahydrofolate reductase (NADPH) which results in functional loss [1]. Homozygous TT genotype carriers...
中国汉族人群中CC型频率为25.9%，CT型频率为44.9%，TT型频率为29.2%3，对8 篇文献中M THFR 基因677位点C→T和1298位点A→C的Meta 分析结果表明,MTHFR 基因C677T与生精功能下降显著相关(OR = 1. 39, 95%C I: 1. 1522. 69, P = 0. 000 6) 。通过对2001至2009年共24篇男性不育相关文献中...
However, the serum levels of vitamin B2 and B12 and the MTHFR C677T genotypes interact in ways which has a different effect on the EPL and ESCC risks. For the homozygous wild genotype CC subjects who have normal activity of MTHFR, high serum levels of vitamin B2 and B12 were significantly...
Cláudia PMS Oliveira1*, Maria TC Muniz3, Filipe Silva3, Leila MMB Pereira2,4 and Flair J Carrilho1 Abstract Background/Aim: Hyperhomocysteinemia due to Methylenetetrahydrofolate Reductase (MTHFR) gene, in particular the C677T (Ala222Val) polymorphism were recently associated to steatosis and ...
The assay analyzes the C-to-T mutation occurring at nucleotide 677 of the gene MTHFR (Methylen-tetra-hydro-pholate reductase) involved in the re-methylation of homocysteine to methionine. This mutation leads to decreased enzymatic activity, with increased plasmatic levels of homocysteine...
Therefore, the homozygous form of the variant allele, MTHFR 677TT genotype, is associated with higher blood concentrations of Hcy than carriers of the 677CC or the 677CT genotypes. The influence of the MTHFR C677T polymorph- ism was clearly confirmed in genome-wide association studies.15,16 ...