Results ①The homozygous mutation rate is 11.3% among the 53 chinese children with han nationality. DS group got remarkable higer mutation rate of MTHFR C677T than control group(P0.05). DS group had significantly higher T allele frequency(P0.05);②The plasma level of Hcy was remarkable higher...
[ꎻ]ꎻ结论:兆偏头痛无明确相关ꎻ基因型能增加先兆型偏头痛发病风险ꎻ关键词亚甲基四氢叶酸还原酶ꎻꎻ偏头痛ꎻ分析文章编号:中图分类号:文献标识码:AssociationbetweenhomozygousC677TmutationinMTHFRgeneandmigraineameta~analysisZuoYanfangLiMingGuoYiGaoZhanDepartmentofNeurologyLonggangDistrictCentralHospitalof...
Acronyms A gene on chromosome 1p36.3 that encodes an enzyme which converts 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Molecular pathology Defects in MTHFR cause methylenetetrahydrofolate reductase deficiency and increase sucepti...
MTHFR C677T homo- zygous as risk factor for complications after OLT for cryptogenic cirrhosis. Clin Transplant 2006;20:796-798.Pasta L, Marrone C, D'Amico M et al. MTHFR C677T homozygous as risk factor for complications after OLT for cryptogenic cirrhosis. Clin Transplant 2006; 20: 796- ...
Meta-analyses of a total 11 studies showed no association between MTHFR 677C>T polymorphism and cervical cancer using all five genetic models (All P values > 0.05). However, subgroup analyses showed the odds of the homozygous TT genotype were much less in cervical cancer cases than in ...
The common MTHFR C677T polymorphism produces an enzyme with reduced activity [5] owing to lowered affinity for its riboflavin cofactor, (flavin adenine dinucleotide, FAD) [6]. The homozygous MTHFR 677TT genotype affects 2–32% of populations worldwide [7] and meta-analyses have estimated that...
其中同型半胱氨酸(Homozygous)基因突变指的是“cc”,比如C677T等类似的突变。“cc”的意思是检测结果证明患者拥有两个同源的突变MTHFR基因,即被检测的动物具有两个相同的变性叶氨酸变换酶(MTHFR)基因。这种情况需要进一步检测,以确定病人是否在某些方面受到影响,并因此需要因应的治疗。同时,还应注意与MTHFR基因突变有...
名义上 200X 深度的全外显子测序结果，MTHFR 677,C/T 杂合 这个 200X 的全外显子测序也不能保证...
ResultsIn this study, the frequencies of wild type (CC), heterozygous mutant (CT), and homozygous mutant (TT) of MTHFR gene C667T were 46.68%, 43.36%, and 9.96%, respectively; and the frequency of mutant allele T was 31.64%. The frequencies of TT genotype and allele T of MTHFR C667...
o g i s t i c多元回归方程分析影响HU A发生的因素,通过分层分析㊁相对超危险度比(R E R I)㊁归因比(A P)㊁交互作用指数(S)评价肥胖与MT H F R C677T基因多态性对HU A的交互作用㊂结果 HU A组B M I㊁收缩压㊁高脂血症患者占比较对照组高(P<0.05);HU A组T T基因型频率㊁T...