[ꎻ]ꎻ结论:兆偏头痛无明确相关ꎻ基因型能增加先兆型偏头痛发病风险ꎻ关键词亚甲基四氢叶酸还原酶ꎻꎻ偏头痛ꎻ分析文章编号:中图分类号:文献标识码:AssociationbetweenhomozygousC677TmutationinMTHFRgeneandmigraineameta~analysisZuoYanfangLiMingGuoYiGaoZhanDepartmentofNeurologyLonggangDistrictCentralHospitalof...
Results ①The homozygous mutation rate is 11.3% among the 53 chinese children with han nationality. DS group got remarkable higer mutation rate of MTHFR C677T than control group(P0.05). DS group had significantly higher T allele frequency(P0.05);②The plasma level of Hcy was remarkable higher...
Acronyms A gene on chromosome 1p36.3 that encodes an enzyme which converts 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Molecular pathology Defects in MTHFR cause methylenetetrahydrofolate reductase deficiency and increase sucepti...
Meta-analyses of a total 11 studies showed no association between MTHFR 677C>T polymorphism and cervical cancer using all five genetic models (All P values > 0.05). However, subgroup analyses showed the odds of the homozygous TT genotype were much less in cervical cancer cases than in ...
2.C 677 T homozygous MTHFR mutation in 4 % , and oral contraceptive use in 22 %. 4%C677T纯合亚甲基四氢叶酸还原酶变异;22%使用口服避孕药. 3.Objective To evaluate the relationship between 5, 10 - Methylenetetrahydrofolate reductase ( MTHFR ) gene polymorphisms and colorectal cancer ( CRC )...
The common MTHFR C677T polymorphism produces an enzyme with reduced activity [5] owing to lowered affinity for its riboflavin cofactor, (flavin adenine dinucleotide, FAD) [6]. The homozygous MTHFR 677TT genotype affects 2–32% of populations worldwide [7] and meta-analyses have estimated that...
This study aimed to investigate if the homocysteine-lowering efficacy of two commonly used physiological doses (0.4 mg/d and 0.8 mg/d) of folic acid (FA) can be modified by individual methylenetetrahydrofolate reductase (MTHFR) C677T and/or methionine synthase (MTR) A2756G polymorphisms in ...
this study, the frequencies of wild type (CC), heterozygous mutant (CT), and homozygous mutant (TT) of MTHFR gene C667T were 46.68%, 43.36%, and 9.96%, respectively; and the frequency of mutant allele T was 31.64%. The frequencies of TT genotype and allele T of MTHFR C667T ...
MTHFR C677T homozygous as risk factor for complications after OLT for cryptogenic cirrhosisdoi:10.1111/j.1399-0012.2006.00564.xLindaInternalPastaInternalCiroInternalMarroneInternalMarioInternalD'AmicoInternalRobertoInternalVerdoneInternalAroldoInternalRizzo...
o g i s t i c多元回归方程分析影响HU A发生的因素,通过分层分析㊁相对超危险度比(R E R I)㊁归因比(A P)㊁交互作用指数(S)评价肥胖与MT H F R C677T基因多态性对HU A的交互作用㊂结果 HU A组B M I㊁收缩压㊁高脂血症患者占比较对照组高(P<0.05);HU A组T T基因型频率㊁T...