Results ①The homozygous mutation rate is 11.3% among the 53 chinese children with han nationality. DS group got remarkable higer mutation rate of MTHFR C677T than control group(P0.05). DS group had significantly higher T allele frequency(P0.05);②The plasma level of Hcy was remarkable higher...
[ꎻ]ꎻ结论:兆偏头痛无明确相关ꎻ基因型能增加先兆型偏头痛发病风险ꎻ关键词亚甲基四氢叶酸还原酶ꎻꎻ偏头痛ꎻ分析文章编号:中图分类号:文献标识码:AssociationbetweenhomozygousC677TmutationinMTHFRgeneandmigraineameta~analysisZuoYanfangLiMingGuoYiGaoZhanDepartmentofNeurologyLonggangDistrictCentralHospitalof...
Acronyms A gene on chromosome 1p36.3 that encodes an enzyme which converts 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Molecular pathology Defects in MTHFR cause methylenetetrahydrofolate reductase deficiency and increase sucepti...
2.C 677 T homozygous MTHFR mutation in 4 % , and oral contraceptive use in 22 %. 4%C677T纯合亚甲基四氢叶酸还原酶变异;22%使用口服避孕药. 3.Objective To evaluate the relationship between 5, 10 - Methylenetetrahydrofolate reductase ( MTHFR ) gene polymorphisms and colorectal cancer ( CRC )...
The C677T mutation can occur in one of three ways: No mutation (CC).The person inherits two normal copies of the gene. Heterozygous mutation (CT).The person inherits one normal copy and one mutated copy. Homozygous mutation (TT).The person inherits two mutated copies. ...
目的通过构建体外质粒DNA作为质控样本开展MTHFR677基因检测室间质量评价计划(简称室间质评),评估参评实验室检测能力及存在的问题,提高临床实验室MTHFR基因检测质量。 方法利用基因工程技术体外构建含有MTHFR677位点野生型(C)上下游序列的重组质粒,并采用定点突变技术得到该位点的突变型(T),分别作为野生型和突变型样本,两者...
o g i s t i c多元回归方程分析影响HU A发生的因素,通过分层分析㊁相对超危险度比(R E R I)㊁归因比(A P)㊁交互作用指数(S)评价肥胖与MT H F R C677T基因多态性对HU A的交互作用㊂结果 HU A组B M I㊁收缩压㊁高脂血症患者占比较对照组高(P<0.05);HU A组T T基因型频率㊁T...
Introduction: Hyperhomocysteinemia is an independent risk factor for cerebrovascular disease and the homozygous C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene can induce hyperhomocysteinemia. However, the association between this 677TT genotype and ischemic stroke still remains contro...
结论 MTHFR C677T的3种基因型频率在宁夏汉族冠心病患者和正常人群中的分布无统计学意义.MTHFR基因C677T多态性与冠心病的危险因素Hcy水平、叶酸水平相关.%Objective To investigate the correlation between methylenterahydrofolate reductase (MTHFR) gene C677T polymorphism, homocysteine (Hcy), folate and coronary ...
冠心病患者血浆Hcy、高敏CRP与MTHFR C677T基因突变 的临床意义探索 摘要 目的 比较不同冠心病类型及不同病变冠脉范围血浆同型半胱氨 酸(Hey)、高敏C反应蛋白(hs.CRP)水平差异。分析亚甲基四氢 叶酸还原酶(MTHFR)C677T基因多态性与血浆Hcy水平影响,与冠 心病的关系。 方法235名研究对象均来自湖南地区汉族人群,其中...