The aim of this study was to evaluate the impact of methylene tetrahydrofolate reductase (MTHFR) rs1801133 (C→T667 transition) on age at first idiopathic portal vein thrombosis (PVT) and to identify clinical and/or laboratory variables influencing age at first PVT, including plasma homocysteine ...
We found that both the heterozygous CT (adjusted OR = 0.78, 95% CI: 0.67–0.92) and the homozygous TT genotypes (adjusted OR = 0.68, 95% CI: 0.55–0.83) of c.677C>T were associated with a significantly decreased risk of PCa compared with homozygous wild-type CC genotype, ...
If an individual with CFS also carries an MTHFR mutation, especially if they are homozygous for C677T (having two copies of the mutation), the resulting elevated homocysteine levels could potentially exacerbate their symptoms. In terms of treatment, the primary goal for individuals with MTHFR mutat...
and having a greater number of variations doesn’t always mean the person will have more symptoms. I personally have two copies of the MTHFR mutation and am alive and well (with some interventions), while others I have seen have just
If 80% of everyone you see walking down the street has a COMT gene imbalance, wouldn’t you expect that 80% of people would have stress-mess symptoms which come from a slowed COMT pathway? Wouldn’t it make sense that if 80% of the population have a slowed COMT pathway that stress wo...
A couple of weeks ago, amongst the many reports of awaited test results, which thankfully all were ok but one, I was informed that I am carrying two copies (homozygous) of the MTHFR gene c.665C>T variant. I am sure when reading this you’ll think, what does that mean? Well that’...
In many nations the commonness of the heterozygous type of FH, in which a faulty gene for the LDLR is acquired from one parent and a normal gene from another is 1:500 and that of the homozygous form is 1:1,000,000 people which renders FH likely the most well-known illness created by...
First, the homo- zygous wild-type (C/C) carriers had lower T1/2 values (P = 0.003) and higher Ke values (P = 0.008) as compared to homozygous variant (T/T) carriers. Second, when com- paring T/T with (C/T) genotypes, there were significant differences for AUC0-t, AUC0-∞, ...
a). Her mother had the homozygous c.665 C > T variant in MTHFR. Fig. 2 Breakpoint analysis of loss of heterozygosity The primers were designed for polymerase chain reaction (PCR) from Chr 1: 11834885 to Chr 1: 11868856. Because of the distance between the primer-binding sites on...
(source) Attempts to mask symptoms of digestive distress can make matters even worse. For example, antacids interfere with the absorption of vitamin B-12, which is essential for helping the body use folate. Though I don’t have any obvious digestive issues, I know that nourishing the gut ...