分子特征数据库(MSigDB)结果显示,血清反应因子(SRF)在肝硬化的细胞骨架和迁移基因中高度富集(图1B)。SRF通过其主要共激活因子MRTFA和MRTFB介导细胞骨架基因表达和细胞迁移。为了探究肝纤维化过程中肝脏MRTF的表达情况,作者对健康和肝硬化...
MRTF/SRF-IN-1 | MedChemExpress (MCE) 英文名称: 总访问: 68 国产/进口: 进口 半年访问: 7 产地/品牌: MedChemExpress(MCE) 产品类别: 生化试剂 规格: 电询 最后更新: 2025-2-13 货号: HY-153078 CAS 号: 1922098-90-5 参考报价: 电询 立即询价 电话咨询 ...
CCG-203971 是一种第二代 Rho/MRTF/SRF 通路抑制剂,CCG-203971 可抑制 PC-3 细胞迁移(IC50值为4.2 μM)。 产品性质 英文别名(English Synonym) CCG-203971 中文名称(Chinese Name) / 靶点(Target) others 通路(Pathway) GPCR/G Protein CAS号(CAS NO.) ...
TGF-尾 signaling activity was significantly attenuated, whereas that of the BMP pathway augmented by inhibition of SRF or MRTF-A/MRTF-B, leading to enhanced brown adipocyte differentiation. Our study demonstrates the MRTF-SRF transcriptional cascade as a negative regulator of brown adipogenesis, ...
一旦游离在细胞质中,MRTF-A 就被转运到细胞核中,在那里它与 SRF 结合以激活靶基因的转录,特别是 CTGF。通过对静态和拉伸状态下细胞中的 MRTF-A 进行免疫染色(图4 A)和相对于细胞的总荧光定量核标记(图4 B)来评估该过程。 ...
Interpretation Our study is the first, to our knowledge, to show that silencing the MRTF/SRF pathway significantly decreases matrix contraction, fibroblast protrusive behaviour, matrix degradation, and MMP gene expression in fibrotic human conjunctival fibroblasts. Our study suggests that inhibiting the ...
Mrtf-null HSC/Ps were also defective in chemotactic responses to SDF-1. Srf-null HSC/Ps exhibit substantial deficits in cytoskeletal gene expression. MRTF-SRF signaling is thus critical for expression of genes required for the response to chemokine signaling during hematopoietic development....
MRTF/SRF-IN-1 型号: 参考价:￥咨询 mrtf/srf-in-1 (example 41) 是心肌素相关转录因子和血清反应因子 (mrtf/srf) 的抑制剂。mrtf/srf-in-1 可用于预防癌症和纤维化的研究。 所在地:美洲 查看详情索取资料 1共1页 快速导航 企业档案 产品分类 ...
The myocardin-related transcription factor/serum response factor (MRTF/SRF) pathway represents a promising therapeutic target to prevent fibrosis. We have tested the effects of new pharmacological inhibitors of MRTF/SRF signalling in a preclinical model
它作为血清反应因子(serum response factor,SRF)转录因子的强效共激活剂,能与血清反应元件(serum-response elements,SREs)结合,调节影响细胞分化、ECM 重塑和纤维化的转录过程。鉴于 MRTF-A 在基质硬度机械转导中的作用,以及基质硬度与糖酵解之间可能存在的联系,研究人员推测 MRTF-A 可能是 ECM 硬度与糖酵解之间的...