CCG-203971 是一种第二代 Rho/MRTF/SRF 通路抑制剂,CCG-203971 可抑制 PC-3 细胞迁移(IC50值为4.2 μM)。 产品性质 英文别名(English Synonym) CCG-203971 中文名称(Chinese Name) / 靶点(Target) others 通路(Pathway) GPCR/G Protein CAS号(CAS NO.) ...
Here we investigated the role of the SRF network in the immediate transcriptional response of fibroblasts to serum stimulation. SRF recruited its cofactors in a gene-specific manner, and virtually all MRTF binding was directed by SRF. Much of SRF DNA binding was serum-inducible, reflecting a ...
CCG-257081 (MRTF/SRF-IN-1) 是心肌素相关转录因子和血清反应因子 (MRTF/SRF) 的抑制剂,通过抑制 Rho/MRTF/SRF 通路来发挥作用。CCG-257081 已在多个小鼠模型中显示出预防博莱霉素诱导的纤维化的功效。CCG-257081 可用于预防癌症和纤维化的研究。 规格价格库存数量 ...
R.R.N. is a President and Founder of Fibrosix, Inc. R.R.N. and E.M.L. are part of the following patent “Inhibitors of Myocardin-Related Transcription Factor and Serum Response Factor (MRTF/SRF)-Mediated Gene Transcription and Methods for use of the same”, Serial Number 14/934,769...
CCG-257081 (MRTF/SRF-IN-1) 是心肌素相关转录因子和血清反应因子 (MRTF/SRF) 的抑制剂,通过抑制 Rho/MRTF/SRF 通路来发挥作用。CCG-257081 已在多个小鼠模型中显示出预防博莱霉素诱导的纤维化的功效。CCG-257081 可用于预防癌症和纤维化的研究。 RasRho ...
S8469 CCG-203971 CCG-203971 is a novel small-molecule inhibitor of the Rho/MRTF/SRF pathway with the IC50 value of 0.64 μM for SRE.L. It inhibits Rho-mediated gene transcription. Biomedicines, 2023, 11(9)2351 J Cell Physiol, 2020, 235(5):4790-4803 Small GTPases, 2020, 10.1080/...
While CTGF transcript levels are often used to infer endogenous YAP1/TEAD activity, both SRF22and TEAD21directly bind and activate the CTGF promoter. Further, F-actin formation promotes MRTF to enter the nucleus where it forms a complex with SRF that directly binds and activates the CTGF promot...
localization of FLAG-MRTF-A, and the effect of MRTF-A overexpression on smooth muscle alpha-actin promoter activity was inhibited by dominant negative RhoA... K Lockman,JS Hinson,MD Medlin,... - 《Journal of Biological Chemistry》 被引量: 286发表: 2004年 EphrinA1 inactivates integrin-mediated...
Recently, mouse ISG15 was found to be regulated by the MRTF-A/SRF transcription factor machinery (Hermann et al., 2016). Here, we tested whether the MRTF-A/SRF transcription factor machinery is part of the suppression mechanism that downregulates ISG15 in DOCK6 KO cells. SRF binds to a ...
Disclosed herein are inhibitors of Rho/MRTF/SRF-mediated gene transcription, and methods for their use in treating or preventing diseases such as cancer and fibrosis. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salts thereofScott D. Larsen...