[1]在H9c2细胞中,CCG-1423抑制MRTF核定位,并阻断STARS近端报告基因活性。[2]CCG-1423,作为一种Rho/MRTF/SRF信号通路抑制剂,也会抑制人结肠肌成纤维细胞中基质僵硬和TGF-β诱导的纤维增生。[3] 参考文献 .Evelyn CR, et al. CCG-1423: a small-molecule inhibitor of RhoA transcriptional signaling.Mol ...
and binding to the monomer keeps it in the cytoplasm. Not G-actin bound MRTF-A in contrast translocates into the nucleus, where it binds and activates SRF [90]. As RhoA activation stimulates and stabilizes actin-polymerization, it reduces the amount of G-actin in the cytoplasm, thus increasi...
YAP and MRTF-A, transcriptional co-activators of RhoA-mediated gene expression, are critical for glioblastoma tumorigenicity. Oncogene. 2018;37:5492–507 Zhang T, Xue L, Li L, Tang C, Wan Z, Wang R, et al. BNIP3 Protein Suppresses PINK1 Kinase Proteolytic Cleavage to Promote Mitophagy. J...
Here, we show that in human developing cardiomyocytes cell-cell contacts at the intercalated disk connect to remodeling of the actin cytoskeleton by regulating the RhoA-ROCK signaling to maintain an active MRTF/SRF transcriptional program essential for cardiomyo- cyte identity. Genetic perturbation of ...
In addition to the promotion of SRF translocation into the nucleus, RhoA can increase SRF activity even more by stimulating co-activators of SRF. An important co-activator of SRF is the "myocardin-related transcription factor A" (MRTF-A, also named MKL1). In experiments in mice we have ...
PCP通路与平滑肌细胞分化的关系探讨,王利凤,徐安恬,小G蛋白RhoA介导的肌动蛋白(actin)多聚化和SMC特异基因转录装置CArG(肌特异基因DNA 基序)-SRF(转录因子)-MRTF(辅激活因子)复合物的 上传者:weixin_38588854时间:2020-02-02 ErbB_HER 信号通路图 ErbB_HER 信号通路图 包括EGFR HER2 HER3 HER4 及相关下游的...
Association of MRTF-Awith G-actin results in its sequestration in the cytoplasm.Serum stimulation and other signals that activate RhoApromote actin polymerization [188, 190, 191] , leading toMRTF-A translocation into the nucleus and SRF target geneactivation [179, 188, 192]. Immediate-early ...
The role of YAP (Yes-associated protein 1) and MRTF-A (myocardin-related transcription factor A), two transcriptional co-activators regulated downstream of GPCRs (G protein-coupled receptors) and RhoA, in the growth of glioblastoma cells and in vivo glioblastoma multiforme (GBM) tumor development...
The Rho GTPase signaling pathway is responsible for cell-specific processes, including actin cytoskeleton organization, cell motility, cell division, and the transcription of specific genes. The implications of RhoA and the downstream effector ROCK2 in c
In addition, hearts from mice with cardiomyocyte-specific RhoA deficiency also showed less fibrosis in response to chronic TAC, with decreased transcriptional activation of genes involved in fibrosis, including myocardin response transcription factor (MRTF) and serum response factor (SRF), suggesting that...