它作为血清反应因子(serum response factor,SRF)转录因子的强效共激活剂,能与血清反应元件(serum-response elements,SREs)结合,调节影响细胞分化、ECM 重塑和纤维化的转录过程。鉴于 MRTF-A 在基质硬度机械转导中的作用,以及基质硬度与糖酵解之间可能存在的联系,研究人员推测 MRTF-A 可能是 ECM 硬度与糖酵解之间的调...
mouse IF Nat Cell Biol Myc-dependent dedifferentiation of Gata6+ epidermal cells resembles reversal of terminal differentiation Authors - Miguel Bernabé-Rubio View Article IF J Cell Biol The actin-MRTF-SRF transcriptional circuit controls tubulin acetylation via α-TAT1 gene expression. Authors - Jaim...
at least in part may underlie augmented MRTF activity. While the mechanisms regulating MRTF expression have not been extensively characterized, actin remodeling and TGFβ were reported to increase MRTF mRNA in an SRF-dependent manner65,66. Our data showing that MRTF expression per se was...
SRF is a ubiquitous transcription factor that was first identified as a regulator of growth-factor regulated immediate-early genes. Working in partnership with its coactivators MRTF-A and MRTF-B, SRF regulates the majority of cytoskeletal genes7,8, including many that are involved in fibrosis9,10...
We analysed muscle biopsies from human subjects to verify if our findings in murine muscle also translate to exercise in humans Results We identified a new phosphorylation site on Myocardin㏑elated Transcription Factor B (MRTF〣), a co゛ctivator of Serum Response Factor (SRF). Phosphorylation of ...
9 Here, we confirm that SRF siRNA depletion decreases β1-integrin protein expression in PC3 cells (Figure 5G).53 IQGAP1 and NWASP depletion reduced β1-integrin mRNA levels (Figures 5H and S5J), indicating that IQGAP1 and NWASP could mediate the effect of Cdc42 on β1-integrin ...
This result could be rationalized by another novel finding reported here; that is, HDAC6 inhibition elevated acetylation and total protein of myocardin-related transcription factor A (MRTF-A), a master regulator that can activate SRF-directed contractile gene transcription if undergoing a cytosol–...
Previous studies have demonstrated that myocardin-related transcription factor A (MRTF-A) generates a link between the dynamics of the actin cytoskeleton and gene expression with its coregulator, serum response factor (SRF). MRTF-A has also been suggested as a regulator of stem cell differentiation...
MRTF-A could interact with SRF and strongly activate the target genes by binding on the highly conservative cis-acting element CC(A/T) 6 GG (CArG box) in the pro- moter [2]. Besides its well-known roles in cardiovascular regula- tion, increasing evidence has suggested that MRTF-A might...
MRTF-A is a transcriptional coactivator that physically associates with the SRF and synergistically activates transcription, thus regulating a variety of biological processes, such as proliferation, differentiation, apoptosis, and fibrosis.45,46 It represents a central relay in stiffness mechanotransduction ...