MRL-Lpr小鼠是一种常用于研究自身免疫疾病的实验小鼠模型,特别是在系统性红斑狼疮(SLE)和其他自身免疫性疾病方面。这些小鼠携带一种名为Fas(或Lpr,lymphoproliferation)的突变基因,这一突变导致了Fas受体功能的丧失。Fas受体在调节细胞凋亡中起关键作用,其功能缺失会导致异常的免疫细胞增生和自身免疫反应。
Creative Bioarray provides customers with MRL/lpr mouse model to study mechanisms of systemic lupus erythematosus and test the efficacy of drug candidates targeting SLE.
The MRL-lpr/lpr mouse: a potential model of autoimmune inner-ear disease. Acta Oto Laryngologica 1993;113:160-165.Ruckenstein MJ, Mount RJ, Harrison RV. The MRL-lpr/lpr mouse: a potential model of autoimmune inner ear disease. Acta Otolaryngol Head Neck Surg. 1993; 113 :160–165....
andBcellactivationinMRL/Iprmouse Xiao～ ,G 刀l一ng,H ⅣGring,WANGDan—dan, LlNJing,LIUHui-qing,SUNLing-yun.DepartmentofRheumatologyandImmunology,theAffiliatedDrum TowerHospital,MedicalSchoolofNanjingUniversity,flangsu210008, China Correspondingauthor:SUⅣLing-yun.Email:ingyunsun2001C~ahoo.com,.cn ...
PPAR γ ligand attenuates portal inflammation in the MRL-lpr mouse: a new strategy to restrain cholangiopathy in primary biliary cirrhosis. Medical Molecular Morphology . 2013; 46 (3):153–159.Y. Nozaki, K. Harada, T. Sanzen, and Y. Nakanuma, "PPAR𝛾 ligand attenuates portal inflammation...
11. White Mouse, Gray Mouse and Yellow Mouse go to visit Piggy. 小白鼠、灰鼠、黄鼠到树林里去看望小猪。12. A kangaroo carries its young in a pouch. 大袋鼠以肚袋装小袋鼠。13. ""Run and fetch it,Mousy." ""跑步去拿,小老鼠。14. such as white mice and birds. 比如小白鼠和小鸟。
离心浓缩后 ,加入 anti.mouse.CD40.PE 、anti.mouse. 徐卫东等 纳米雄黄影响 MRL/Ipr小 鼠 B 细胞表型和功能的初步研究 第12 期 CD69.FITC 混匀后 ,4 ℃避光作用 3O 分钟,PBS 洗涤 细胞2 次( 1 200 r/min,5 分钟) ,以4%多聚甲醛 固
The MRL/lpr mouse was thought to be a good experimental model to study the spontaneous sensorineural hearing loss caused by an immune reaction. 展开 关键词: AUDITORY BRAIN STEM RESPONSE AUTOIMMUNITY IMMUNOELECTRON MICROSCOPY MRL LPR MOUSE STRIA VASCULARIS DOI: 10.1288/00005537-199211000-00020 ...
【Key words】MRL/lpr; Systemic lupus erythematosus; CD4+CD25+ regulatory T cells; Mouse CD4+CD25+调节性T细胞(regulatory 7、 T cell,Tr)是健康个体T细胞群的重要成员,通过与靶细胞的相互接触、下调靶细胞上白介素(IL)2R的表达,以及抑制抗原提呈细胞(APC) 提呈抗原而抑制免疫应答。除CD25外,这群细胞还...
Taken together, these studies show that EGCG attenuated inflammation in MRL/lpr mouse mesangial cells via the PI3K/Akt/mTOR pathway. Our findings suggest a potential therapeutic role for the use of EGCG to regulate inflammation and control autoimmune disease. This is a preview of subscription ...