Kotzin BL, et al. (2008) Systemic lupus erythematosus in MRL/lpr mice is independent of complement component 4. J Immunol. 181(6): 3783-3792. 返回列表 查看MRL-lpr 小鼠产品说明书 与唯尚立德一起,共同创造更多价值。
将淋巴增生阳性小鼠和阴性小鼠(MRL/MpJ)进行回交育种,培育成具有同样遗传背景的品系,即MRL/MpJ-Faslpr/J小鼠(详情请查看:jax.org/jax-mice-and-se)。因此可以使用MRL/MpJ小鼠作为对照小鼠。在JAX,MRL/MpJ-Faslpr和MRL/MpJ对照品系通过定期的杂交和回交来保持相互之间的同源性。 MRL/Lpr小鼠表型 MRL/Lpr模型的...
3.淋巴结肿大和皮肤病变（表3）表3疾病的明显迹象。Female (F) and male (M) MRL-lpr mice were ...
MRL-lpr mice develop a lymphoproliferative disorder characterized by features of systemic lupus erythematosus and by massive proliferation of a subpopulation of Lyt-1+23- T cells. Using fluorescein-conjugated monoclonal antibodies and the fluorescence-activated cell sorter, we have found an abnormal ...
1)MRL/lpr miceMRL/lpr小鼠 1.ses activity in serum and urine of MRL/lpr mice with ageing and its significance;MRL/lpr小鼠血清与尿液中明胶酶活性的增龄变化及意义 2.To determine the distribution of IL-4,IFN-γand IL-17 in lacrimal gland lesions,submaxillary lymph nodes of MRL/lpr mice——...
The Study on the Role of OBF-1 for Antibody-Secreting Cells and Autoimmunity in MRL-lpr Mice; OBF-1对MRL-lpr小鼠抗体分泌细胞产生及自身免疫发展的功能研究 5. The Study of the Expression of Cyclin-Dependent Kinase Inhibitor P21 in Renal Tissue of MRL/lpr Mice and the Effect of Leflunomide;...
MRL-lpr/lpr mice were treated with Tripterygium Wilfordii Hook-F (TWHF), a Chinese herbal medicine successfully used for human rheumatoid arthritis. Dramatic prolongation of survival and the reduction of urinary protein were observed in mice treated with a high dose of TWHF (20 mg/kg, three ...
1.Objective To explore the influence of leflunomide on Janus protein-tyrosine kinase(JAK)/signal transducer and activator of transcription(STAT) signal transduction pathway in renal tissue of MRL/lpr lupus mice.目的探讨来氟米特对MRL/lpr狼疮小鼠肾脏JAK/STAT1信号转导途径的影响。 2)MRL/lpr miceMRL/...
The present study was undertaken using 1H and 13C nuclear magnetic resonance (NMR) spectroscopy to determine the rates of incorporation of glucose into amino acids and lactate via cell-specific pathways in mice with lupus. In the well-established MRL/lpr lupus mouse model, 24-week-old mice ...
Keywords:Autoimmunity;Dendrites;Spines;Inflammation;Hippocampus;Parietalcortex;Lupus;Interleukin-6;Stress;MRL-lprmice;Behavioral immunology 1.Introduction ThehallmarkphenomenaininbredMRLrMpJ-lpr Ž.Ž.MRL-lprandMRLrMpJqrqMRLqrqmurine substrainsarehypermaturity,acceleratedagingandsponta- neousdevelopmentofa...