MRL/MpJ-Faslpr/J (MRL-lpr) mice develop an autoimmune disease resembling systemic lupus erythematosus, a disease affecting > 1.5 million Americans. The causative mutation, Faslpr, promotes survival of self-reactive lymphocytes, leading to immune proliferation, lymphadenopathy, emergence of anti-DNA ...
Creative Bioarray provides customers with MRL/lpr mouse model to study mechanisms of systemic lupus erythematosus and test the efficacy of drug candidates targeting SLE.
In the present investigation, we examined hearing thresholds and cochlear histologies of the MRL/lpr mouse which is now well-known as a model for pathology consistent with systemic lupus erythematosis (SLE). Present findings demonstrated that there were no statistically significant differences in ...
Oral ruxolitinib, a Janus kinase inhibitor, has been shown to be effective in preventing skin disease in the MRL/lpr mouse model of lupus. Topical ruxolitinib has not been studied in the MRL/lpr model or in human CLE, but has recently been approved for atopic dermatitis. In this study, ...
1.Objective To explore the influence of leflunomide on Janus protein-tyrosine kinase(JAK)/signal transducer and activator of transcription(STAT) signal transduction pathway in renal tissue of MRL/lpr lupus mice.目的探讨来氟米特对MRL/lpr狼疮小鼠肾脏JAK/STAT1信号转导途径的影响。 2)MRL/lpr miceMRL/...
Lupus erythemetosusMRL/lpr miceWe investigated the effects of cyclosporin A (CyA) on the development of lupus dermatoses in autoimmune-prone MRL/Mp-lpr/lpr (MRL/lpr) mice. The MRL/lpr mouse is an animal model for the spontaneous development of skin lesions similar to those of human lupus...
目的探讨小窝蛋白(caveolin)-1对MRL/lpr狼疮小鼠肾损伤及肾小球紧密连接蛋白的作用。 方法实验分为4组:正常对照组(BALB/c小鼠):5只;MRL/lpr自发性狼疮小鼠(18只)采用随机数字表法分为:模型组,阴性对照组即空白载体组,caveolin-1转染组,每组6只。检测小鼠尿蛋白定量(24 h)、血尿素氮、肌酐水平的变化。蛋白印迹...
Interferon regulatory factor 5 is critical for the development of lupus in MRL/lpr mice. Arthritis Rheum (2011) 63(3):738-48. doi:10.1002/art.30183Tada, Y.; Kondo, S.; Aoki, S.; Koarada, S.; Inoue, H.; Suematsu, R.; Ohta, A.; Mak, T.W. & Nagasawa, K. (2011). ...
The efficacy of human umbilical cord mesenchymal stem cell (hUC-MSC) transplantation in treating systemic lupus erythematosus (SLE) has been confirmed by small-scale clinical trials. However, these trials focused on severe or refractory SLE, while few st
Likewise, in humans with SLE, peripheral blood T cells have been shown to share an activated phenotype with the T cells that infiltrate kidneys affected by lupus nephritis [18]. Show abstract The MRL/lpr mouse strain as a model for neuropsychiatric systemic lupus erythematosus 2011, Journal of ...