Single-cell whole-genome sequencing methods have undergone great improvements over the past decade. However, allele dropout, which means the inability to detect both alleles simultaneously in an individual diploid cell, largely restricts the application
(http://enhancer.lbl.gov/); mouse CAGE-tag data from the FANTOM5 database44 (https://fantom.gsc.riken.jp/5/); mouse ISH expression data from the Allen Brain Atlas Developing Mouse Brain database (http://developingmouse.brain-map.org/); mouse single-cell ATAC-seq data from Cusanovich...
UCOE (Ubiquitous Chromatin Opening Elements) technology is a breakthrough solution for sustained recombinant protein production and cell line development in mammalian protein expression systems. Warning Toxicity: Standard Handling (A) Legal Information NOVAGEN is a registered trademark of Merck KGaA, Darmsta...
e Expression levels of 139 novel maternal genes and 57 novel zygotic genes in mouse oocytes, normal two-cell embryos and α-Amanitine treated two-cell embryos were analyzed. e (lLeft: the maternal genes show high expression levels in oocyte samples and are largely down-regulated in normal ...
(c) Dot plot of postbud genes in dental mesenchymal cells; dot size showing gene expressed in the fraction of cells in the group; dot color showing the mean expression level of the gene. (d, e) In vivo spatial localization (top) and subcell populations/cell cycles (middle) of E12.5 ...
(RA) due to its enhanced expression in RA-derived bone marrow stromal cell lines. CD157 has been predicted to function as a cell surface receptor and an immunoregulatory molecule. CD157 was originally identified as a bone marrow stromal cell molecule (BST-1) with a glycosylphosphatidylinositol ...
wild-type cells. In single-cell RNA-seq data from resting and activated neutrophils, stimulation with type I and II interferon, G-CSF,E. coliis associated with higher expression of core inflammation genes. Further, neutrophils from COVID-19 patients with more severe disease display higher ...
The computations performed by a neural circuit depend on how it integrates its input signals into an output of its own. In the retina, ganglion cells integrate visual information over time, space, and chromatic channels. Unlike the former two, chromatic
Thus, the expression levels of Acdp1 in these cell types vary a lot, with the highest expression in HEK293 cells. Nevertheless, these immunoblot results support our analysis of brain tissue extracts that the antibody against Acdp1 C-terminus specifically recognizes Acdp-1. The specificity of the...
of secretory goblet and enteroendocrine cells during embryogenesis, and that these defects are associated with the upregulation ofRbp-Jexpression. We further demonstrate that TCF7L1 is required for the differentiation along tuft and enteroendocrine D- and L-cell lineages in the adult small intestine....