By integrating spatial context and multiplexed transcriptional measurements with two single-cell transcriptome atlases, we characterize cell types across the embryo and demonstrate that spatially resolved expression of genes not profiled by seqFISH can be imputed. We use this high-resolution spatial map ...
The mouse Gene Expression Database (GXD) collects and integrates different types of gene expression information, with a focus on endogenous gene expression in wild-type and mutant mice. Because GXD is an integral component of the larger MGI system, its expression data are combined with the geneti...
We labeled each submodule by its expression in one or multiple of the 30 cell types identified by snRNA-seq and tested it for enriched KEGG pathways (Fig. 4c and Methods). Fig. 4: Bacterial presence influences host expression in four major tissue regions. a, Regional association of bacterial...
It may play a role in rheumatoid arthritis (RA) due to its enhanced expression in RA-derived bone marrow stromal cell lines. CD157 has been predicted to function as a cell surface receptor and an immunoregulatory molecule. CD157 was originally identified as a bone marrow stromal cell molecule...
Fig. 1: Extracellular action potential (EAP) recordings from in vivo epxeriments and biophysically realistic single-cell models. Extracellular action potential (EAP) recordings from in vivo experiments (a–d) and single-cell modeling (e–g). a Left, labels for Cre-line and morphology (spiny ...
Table S2. Cell-type-specific gene expression in mouse and human TG, related to Figure 2 Table S3. Cell-type-specific GO terms and ligand-receptor pairs in mouse and human TG, related to Figure 2 Table S4. Differential expression analyses between human and mouse TG cell types, related to ...
In the field of mouse genetics the advent of technologies like microarray based expression profiling dramatically increased data availability and sensitivity, yet these advanced methods are often vulnerable to the unavoidable heterogeneity of in vivo material and might therefore reflect differentially expressed...
A dotted line denotes an indirect interaction and the orange lines indicate potential interaction with those transcription factors added by IPA that are not on the PRG list. Full size image Figure 2 Validation of microarray data by real-time PCR. The levels of expression in two different models...
e Expression levels of 139 novel maternal genes and 57 novel zygotic genes in mouse oocytes, normal two-cell embryos and α-Amanitine treated two-cell embryos were analyzed. e (lLeft: the maternal genes show high expression levels in oocyte samples and are largely down-regulated in normal ...
We provide a searchable, interactive database for exploring gene expression in all these datasets (http://research-pub.gene.com/BrainMyeloidLandscape). Understanding the dimensions of CNS myeloid cell activation in human disease may reveal opportunities for therapeutic intervention. Graphical Abstract ...