Milstein and Köhler did not patent the method, making it free to use by anyone in the world. The monoclonal antibodies produced by hybridoma were proved highly versatile in the laboratory. Besides great insights provided to us in basic immunology research, they become the indispensable tool to...
From the time the first monoclonal antibody was generated in 1975 and the first monoclonal antibody fully licenced in 1986, the field of monoclonal antibody development represents a novel way in which to target specific mutations and defects in protein structure and expression in a wide range of ...
CD138 is a transmembrane protein containing chondroitin sulfate and heparin sulfate moieties responsible for binding to the extracellular matrix components. CD138 is not expressed by mature B cells but is present on pre-B cells and the finally differentiated plasma cells.Applications Reporte...
The resulting complex cleaves protein C and the Thrombin Activatable Fibrinolysis Inhibitor (TAFI), initiating an important anticoagulant and anti-fibrinolytic pathway. Soluble thrombomodulin is constitutively present in the serum at a very low level and can be upregulated during inflammation. The anti-...
DNA-PKCS and FRAP. These proteins have in common a region of homology at their carboxy termini that is not present in the PI 3- and PI 4-kinases. The Atm gene is mutated in the autosomal recessive disorder ataxia telangiectasia (AT) that is characterized by cerebellar degeneration (ataxia)...
A monoclonal antibody (MoAb), Ki-67, recognizes a protein t... JS Ahn,ES Kim,HT Kim,... 被引量: 0发表: 2002年 Evaluation of Ki-67 Monoclonal Antibody as Prognostic Indicator for Prostatic Carcinoma Aliment Pharmacol Ther 31, 1036–1041 Summary Background The calcineurin inhibitor tacrolimus...
In the present study, we report that antibodies against human CD110 used so far are not specific, with the exception of Abbott's MAb1.6.1 [13]. We found that the latter allows sorting of a CD34+CD38−CD110+ population highly enriched in HSCs in adult BM and in CB. Methods Cell lin...
The residues that line the meditope binding site in the Fab are unique to cetuximab and not present in human mAbs1. Therefore, we hypothesized this site could be used as a unique ‘receptor’, not only for potentially attaching cargo2,3, but also for emerging diagnostic techniques such as ...
The implications of immunogenicity for protein-based multiple sclerosis therapies. J. Neurol. Sci. 275, 7–17 (2008). Article CAS PubMed Google Scholar Schellekens, H. Factors influencing the immunogenicity of therapeutic proteins. Nephrol. Dial. Transplant. 20 (Suppl. 6), vi3–vi9 (2005)....
货号14-0681-82 飞享价 CNY1,844.022,458.00 活动截止日期 31-Dec-2024 查看价格 下单后预计有货时间 25-Dec-2024 数量 批量或定制请求 性能保障 说明书 实验方案 技术支持 抗体检测数据 (1) 已发表图片 (17) 高级验证 (1) Application Created with Sketch. ...