Is a monoclonal protein present? The first thing that’s usually done in the lab is serum protein electophoresis (SPEP). This procedure tells you whether there is a monoclonal protein present. You also do this procedure using urine, because sometimes myeloma cells will only make light chains,...
Affinity between the appropriate amino acid residues in the variable region of the antibody and the spike glycoprotein RBD F453 has diminished as cause of weak recognition of monoclonal antibodies for spike glycoproteins. Subspecies of SARS-CoV-2 derived from farmed mink has been observed in samples...
This monoclonal antibody is among the newest drugs to be FDA-approved for treating postmenopausal osteoporosis. It blocks a protein called sclerostin, which controls bone turnover. The dual-acting type of osteoporosis medication helps build bone while reducing bone density loss. ...
Venetoclax (Venclexta) is a type of BCL-2 inhibitor. It's a pill taken once a day. It can be used alone or with a monoclonal antibody. You might have some side effects after taking this drug, such as: Low levels of certain white blood cells (neutropenia) ...
Protein therapeutics, such as monoclonal antibodies (mAb) have been used for the treatment of various diseases.1, 2, 3 Aggregation of mAb, a major stability-related issue,4 is known to occur during various stages of product life cycle such as manufacturing, formulation, transportation, storage ...
- "Target-based drugs": refers to drugs whose discovery process is largely dependent on observing the effect of a molecule on a protein. - "Phenotype-based drugs": refers to those drugs whose discovery process relies primarily on observing the effect of a molecule on the phenotype of an orga...
NGF inhibitors in the form of anti-NGF monoclonal antibodies, are already present as hot drug candidates used in clinical trials and are projected to become the emerging treatment option for chronic pain conditions. Importantly, blockade of NGF will target all pain mechanisms shown in tendons by ...
Bimagrumab is a human monoclonal antibody that stimulates skeletal muscle growth by blocking the activin type II receptor (ActRII) and it is administered as a four-weekly intravenous infusion [96]. In a 48-week phase 2 trial in people with T2D and obesity, 10 mg/kg bimagrumab was asso...
Human glioblastoma cells from three of the patients (AMN, DZ and GA) were used in this present study to evaluate the protein expression of CRP in vitro and human fibroblasts were used as control cells. GFP positive NS1 glioblastoma cells and RG2 cells were used in the rat model. The cells...
Nuclear protein in testis (NUT) carcinomas are very rare, notably among lung cancers, but are very aggressive tumors [276,277,278,279,280,281,282]. These tumors are more frequent in pediatric populations, in particular tumors that develop on the median anatomical axis above the diaphragm [253...