In patients with MGRS, the likelihood of identifying the B-cell clone significantly increases when a serum and/or urine monoclonal protein can be detected. Screening for MIg MGRS can present across a number of clinical scenarios, from isolated proteinuria to end-stage kidney disease. It is ...
where it binds further to the protein transthyretin, to form a transporting complex, which is big enough not to be lost by filtration through the kidney glomeruli. It is detected in nearly all tissues with higher expression in adult ovary, pancreas, pituitary gland, adrenal gland, and fetal li...
The eBio7979 antibody reacts with human and mouse foxp3 protein also known as FORKHEAD BOX P3, SCURFIN, and JM2; cross reactivity of this antibody to other proteins has not been determined. Foxp3, a 49-55 kDa protein, is a member of the forkhead/winged-helix family of transcri...
Mutations in the gene for proteolipid protein () have been associated with dysmyelination and abnormal oligodendrocyte in spontaneous mutants and in ; however, the effect of mutations on structure and function are little understood. We have identified a monoclonal antibody directed against a novel of...
To take advantage of the multiplexed readout of FACS, we then aimed to select specific binding properties detectable during the single-cell screen. As a proof of concept, we isolated antibodies that bind to the S1 region of the spike protein but do not bind to the RBD. We encapsulated B ...
After incubation with secondary antibodies (1:1000 dilution in blocking solution) coupled with infrared dyes (IRDye 800 goat anti-rabbit immunoglobulin G [IgG], IRDye 680 goat anti-mouse IgG and IRDye 680 donkey anti-goat IgG), protein expression was detected using an Odyssey scanner (LI-COR...
Breast cancer is the most common cancer in women diagnosed in the U.S. and worldwide. Obesity increases breast cancer risk without clear underlying molecular mechanisms. Our studies demonstrate that circulating adipose fatty acid binding protein (A-FABP,
detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase...
The 72-kDa protein is not an alternative product of MAGE-1, since it was still detected in lysates of a MAGE-1 loss variant derived from a MAGE-1-positive melanoma cell line. Moreover, the 72-kDa protein does not appear to be a product of the other members of the MAGE gene family ...
In contrast, a Phase II controlled study did not show efficacy at 4 weeks after a single infusion of the antibody, followed by three monthly subcutaneous injections (Reinisch et al., 2010). However, the significant decrease in C-reactive protein (CRP) observed in all patients and the ...