Complete mitogenomes ofNephila pilipes,Trichonephila antipodiana,T. vitiana(previouslyN. vitiana) andT. clavatawith BRIG visualization showing the protein-coding genes, rRNAs and tRNAs. GC skew is shown on the outer surface of the ring whereas GC content is shown on the inner surface. The an...
Cells were starved before the CRC measurements in a 2.5 mM (LG) glucose-containing medium for 24 h. Histograms represent nmols of Ca2+ per µg of protein that are necessary to cause PTP opening. Data are mean (expressed as % of controls) ± SEM of three experiments, *p =...
cerevisiae lacks Complex I. The importance of lipid composition in the stabilization of Complex I-containing SCs is supported by our results showing that reconstitution of binary CI/CIII proteoliposomes from bovine heart at high lipid to protein ratio (30:1 w:w) hampers the assembly of SC I1...
The arrow indicates transcription direction of the protein-coding genes. The genes encoding Complex I proteins are in yellow, those for Complex II are in pink, ATP synthase is in green, other protein coding genes are in purple, tRNAs are in blue, and rRNAs are in red. b Phylogenetic tree...
mitochondrial sirtuin network identified five subnetworks containing known protein complexes, including mitochondrial ribosome large subunit (MRPL), complex I, mitochondrial inner membrane organization system (MitOS/MINOS), oxoglutarate dehydrogenase complex (OGDHC), and pyruvate dehygrogenase complex (PDHC)...
complex because the mitochondrion is encoded by two distinct genomes; the nuclear genome (nDNA) encodes > 1000 gene products that function in the mitochondrion, and the mitochondrial genome (mtDNA) contains 13 protein coding genes, 22 transfer RNAs and two ribosomal RNAs that are expressed ...
protein), and the core subunit and TRAP1 partner UQCRC2 were unaffected. As a control, we also looked at the expression of the complex I component NDUFS1, which was also unaffected upon modulation of TRAP1 expression (Fig.1H). These data suggest that TRAP1 exerts regulation on complex ...
• ADNP forms a complex with SIRT1 through the microtubule end-binding proteins EB1 and EB3. • Mitochondrial gene expression is impaired in the ADNP brain and patient-derived cellular models. Keywords Activity-dependent neuroprotective protein (ADNP), Methylation, ...
protein (Fig.1c). We also observed a loss of mtCU components MCUB and EMRE (Fig.1c), likely attributed to protease mediated degradation of the other structural/channel-forming mtCU components24. Voltage-dependent anion channel (VDAC) and the UQCRC2 (Ubiquinol-cytochrome-c reductase complex ...
TFAM is hydroxylated by EGLN3 and subsequently bound by the von Hippel–Lindau tumour-suppressor protein, which stabilizes TFAM by preventing mitochondrial proteolysis. Cells lacking wild-type VHL or in which EGLN3 is inactivated have reduced mitochondrial mass. Tumorigenic VHL variants leading to ...