This protein is required for the stable interaction between Complex III and Complex IV, but not for the assembly or function of either Complex III or Complex IV. Consequently, Cox7a2l has been renamed SCAF1 for SC assembly factor 1 [11]. The precise function of SCAF1 remains unknown. The...
13. Previous in vitro studies have shown that, under inflammatory conditions, elevated intracellular succinate levels in myeloid cells promote a switch from the normal forward electron transport along the respiratory chain to reverse electron transport (RET) through mitochondrial complex I ...
Detection of components of the mPTP complex was performed using the indicated antibodies. Full size image Fig. 7: Model for the regulation of mitochondrial and cardiac function by MTFP1. (Top) Mtfp1 deletion in cardiomyocytes occurs at birth (cMKO) and sensitizes cardiac myocytes to ...
Clofibrate increased lifespan and motor function of Ndufs4−/− mice, while only marginal hepatotoxic effects were observed. Due to the complex clinical and cellular phenotype of CI-deficiency, we also aimed to investigate the therapeutic potential of clofibrate combined with the redox modulator...
We examined PQQ and mitochondrial function based on observations that PQQ deficiency results in elevated plasma glucose concentrations in young mice, and PQQ addition stimulates mitochondrial complex 1 activity in vitro. PQQ-deficient weanling mice had a 20-30% reduction in the relative amount of ...
Complex V uses the energy created by the proton electrochemical gradient to phosphorylate ADP to ATP. This review covers the architecture, function and assembly of complex V. The role of complex V di-and oligomerization and its relation with mitochondrial morphology is discussed. Finally, pathology ...
Insulin resistance precedes and predicts the onset of type 2 diabetes (T2D) in susceptible humans, underscoring its important role in the complex pathogenesis of this disease. Insulin resistance contributes to multiple tissue defects characteristic of T2
Three proteins, Sam50 (Tob55), Sam35 (Tob38/Tom38), and Sam37 (Mas37), have been identified as the core constituents of the latter complex. Sam37 is essential for growth at elevated temperatures, but the function of the protein is currently unresolved. To identify interacting partners of...
These processes are controlled by several proteins [2], including dynamin-related protein 1 (Drp1) [3, 4], and the mitofusins (for example, Mfn 1 and 2) [5]. Mitochondria also move in a complex way through living cells [6], probably carried by actin/myosin- and dynein/kinesin-based ...
Indeed, the activity of the succinate dehydrogenase complex, which is entirely encoded in the nucleus in Arabidopsis, is unaffected in the OEX plants, while activity of the mt-encoded complexes is greatly perturbed (Figure 3A). Thus, our results suggest that similar mitochondrial dysfunction in ...