The identification of the mitochondrial contact site and cristae organizing system (MICOS) in the inner mitochondrial membrane shed light on the intricate components necessary for mitochondria to form their signature cristae in which many protein complexes including the electron transport chain are ...
protein-rich matrix. To accommodate the volume constraint imposed by the outer membrane, the inner membrane has numerousinvaginations, thecristae, each of which can have one or more tubular connections to the membrane periphery. This “typical”mitochondrial membranemorphology is exemplified in the...
However, increased mRNA and protein levels of complex subunits are found in cancers. This review highlights the importance of the mitochondrial import machinery in human disease and stresses the need for further studies. Ultimately, this knowledge may prove to be critical for the development of ...
What is the role of the inner mitochondrial membrane? The inner mitochondrial membrane is the site of electron transport chain reactions and the synthesis of ATP. The protein and enzyme complexes involved in these processes are embedded in the inner membrane of mitochondria.What...
Substituting amino acid residues with alanine disrupts the correct assembly of a protein complex containing LETM1 and prevents changes in the mitochondrial morphology induced by exogenous LETM1 expression. Moreover, the LETM1 protein changes the shapes of the membranes of in vitro-reconstituted proteo...
Purification of the TbTim17-containing protein complex from the mitochondrial membrane of T. brucei by tandem affinity chromatography revealed that TbTim17 associates with seven unique as well as a few known T. brucei mitochondrial proteins. Depletion of three of these novel proteins, i.e. TbTim...
The inner membrane mitochondrial protein (IMMT) is a central unit of the mitochondrial contact site and cristae organizing system (MICOS). While researchers continue to demonstrate the physiological function of IMMT in regulating mitochondrial dynamics a
Presequence-carrying proteins are imported by the general translocase of the outer mitochondrial membrane (TOM complex) and are handed over to the presequence translocase of the inner membrane (TIM23 complex). The TIM23 complex consists of three core components, the inner membrane proteins Tim17,...
Coupling Chemical Energy by the hsp70/tim44 Complex to Drive Protein Translocation into Mitochondria A dynamic complex between the mitochondrial cognate of hsp70 (mthsp70) and the inner membrane protein tim44 couples energy derived from ATP hydrolysis to d... DM Cyr - 《Journal of Bioenergetics &...
Using the inner mitochondrial membrane as a model subproteome, we compared the ability of three protein separation methods (two-dimensional LC (2-DLC1 with the PF2D), one-dimensional reversed phase HPLC (1-DLC; reversed phase high performance liquid chromatography (RP-HPLC)), and two-...