The identification of the mitochondrial contact site and cristae organizing system (MICOS) in the inner mitochondrial membrane shed light on the intricate components necessary for mitochondria to form their signature cristae in which many protein complexes including the electron transport chain are ...
membrane to ions. The IMM is visualized as a highly convulated structure, made up of several infoldings in the membrane termed ascristaethat project in the internal matrix (Lberts et al., 2008). The inner membrane contains approximately 20% of the protein content of the entire ...
LETM1 is a mitochondrial inner membrane protein that is required for maintaining the mitochondrial morphology and cristae structures, and regulates mitochondrial ion homeostasis. Here we report a role of LETM1 in the organization of cristae structures. We identified four amino acid residues of human...
1.20.3.3.1 Mitochondrion inner membrane proteins of vectorial electron transport The mitochondrial membrane is a protein-rich lamellar array that is characteristic of energy-transducing membranes.90 The chemistry of its function as a respiratory unit was determined by fractionating the lamellae and separa...
A. The mitochondrial inner membrane protein Mitofilin exists as a complex with SAM50, metaxins 1 and 2, coiled-coil-helix coiled-coil-helix domain-containing protein 3 and 6 and DnaJC11. FEBS Lett.581, 3545–3549 (2007). CAS PubMed Google Scholar Rabl, R. et al. Formation of crista...
4b). In addition to the downregulated mitochondrial component genes such as those associated with the mitochondrial complex, mitochondrial inner membrane, and mitochondrial membrane protein complex (Supplemental Fig. 6), 19 downregulated genes were identified, including Atp5e, Prkag2, and Cox8a, ...
Article: The mitochondrial inner membrane protein Lpe10p, a homologue of Mrs2p, is essential for magnesium homeostasis and group II intron splicing
Mitochondria are paramount to the metabolism and survival of cardiomyocytes. Here we show that Mitochondrial Fission Process 1 (MTFP1) is an inner mitochondrial membrane (IMM) protein that is dispensable for mitochondrial division yet essential for cardi
Mitochondrial proteins are proteins that reside within the mitochondria of cells, including within the cristae of the inner mitochondrial membrane. Mitochondrial proteins are generally involved in mitochondrial function, including carrying out reactions of the electron transport chain. Mitochondrial proteins ar...
To date, C-terminal processing of a mitochondrial precursor protein has been reported only for the DNA helicase Hmi1, a matrix protein of 80 kDa loosely associated with the inner membrane42,43. It has been proposed that the last 14 C-terminal residues of Hmi1 are removed by MPP in the ...