Mitochondrial inner membrane protein, Mic60/mitofilin in mammalian organ protectiondoi:10.1002/jcp.27314cristaemorphologyMic60/MitofilinMICOSmitochondriaorgandiseasesThe identification of the mitochondrial contact site and cristae organizing system (MICOS) in the inner mitochondrial membrane shed light on the...
Mitochondrial proteins are proteins that reside within the mitochondria of cells, including within the cristae of the inner mitochondrial membrane. Mitochondrial proteins are generally involved in mitochondrial function, including carrying out reactions of the electron transport chain. Mitochondrial proteins ar...
Mitochondrial inner membrane protein (Mitofilin or Mic60) is a mitochondria-shaping protein that plays a key role in maintaining mitochondrial cristae structure and remodeling. We recently showed that Mitofilin knockdown in H9c2 myoblasts induces mitochondrial structural damage resulting in mitochondrial ...
The mitochondrial inner membrane protein mitofilin controls cristae morphology. Mol Biol Cell. 2005;16:1543–54. Article CAS PubMed PubMed Central Google Scholar Feng Y, Madungwe NB, Bopassa JC. Mitochondrial inner membrane protein, Mic60/mitofilin in mammalian organ protection. J Cell Physiol....
Mic60, also known as Mitofilin, HMP or Fcj1, is a mitochondrial inner membrane protein first identified in the heart13. As a crucial component of the mitochondrial contact site and cristae organizing system (MICOS), Mic60 has been well characterized in controlling mitochondrial morphology14–16...
(A) The submitochondrial distribution profiles of the mtProteome based on compartments: matrix, inner mitochondrial membrane (IMM), outer mitochondrial membrane (OMM), and intermembrane space (IMS). (B) Characterization of mtProteome-based functional properties. Most proteins are involved in various ...
protein-rich matrix. To accommodate the volume constraint imposed by the outer membrane, the inner membrane has numerousinvaginations, thecristae, each of which can have one or more tubular connections to the membrane periphery. This “typical”mitochondrial membranemorphology is exemplified in the...
We recently identified a group of human tumors with constitutively reduced expression of the mitochondrial structural protein, Mic60, also called mitofilin or inner membrane mitochondrial protein (IMMT). These Mic60-low tumors exhibit severe loss of mitochondrial fitness, paradoxically accompanied by ...
背景MIC60 encodes a homolog of the yeast mic60 protein that is localized in the inner membrane of the mitochondrion, interacts with Tom40 as part of a large lipid-enriched complex called the mitochondrial transmembrane lipoprotein compl
John GB, Shang Y, Li L et al (2005) The mitochondrial inner membrane protein mitofilin controls cristae morphology. Mol Biol Cell 16:1543–1554. https://doi.org/10.1091/mbc.E04-08-0697 Article CAS PubMed PubMed Central Google Scholar Jones BA, Fangman WL (1992) Mitochondrial DNA maint...