which manifests as wrinkling, dryness, and mottling. Also, chronic exposure to environmental elements like ultraviolet (UV) radiations cause deleterious effects in the skin cells2. UVA and UVB radiation are not only associated with premature skin photo-aging but also various inflammatory reactions an...
It is therefore not surprising that mitochondrial dysfunction has emerged as a key factor in a myriad of diseases, including neurodegenerative and metabolic disorders. We provide a current view of how mitochondrial functions impinge on health and disease....
Aging is typified by a progressive decline in mitochondrial activity and stress resilience. Here, we review how mitochondrial stress pathways have pleiotropic effects on cellular and systemic homeostasis, which can comprise protective or detrimental resp
Sites of close contact between mitochondria and the endoplasmic reticulum (ER) are known as mitochondria-associated membranes (MAM) or mitochondria-ER contacts (MERCs), and play an important role in both cell physiology and pathology. A growing body of evidence indicates that changes observed in th...
“Our findings showing that stressed telomeres send an RNA message to mitochondria to cause inflammation highlights the need to study interactions between these hallmarks to fully understand aging and perhaps intervene to increase health span in humans.” During the “replicative crisis” that occur...
Advancing age and the associated faltering organs become increasingly vulnerable to diseases with organ systems undergoing an accelerated rapid downward functional spiral; thus, the older an organ is the faster it deteriorates. The rate of organ degeneration during aging is in part related to its ...
The concept of Yang Qi in Traditional Chinese Medicine (TCM) has many similarities with mitochondria in modern medicine. Both are indispensable to human be
Both functions are dependent on the develop- ment of the senescent phenotype, which involves an overproduc- tion of pro-inflammatory and pro-oxidant signals. However, the exact mechanisms regulating these phenotypes remain poorly understood. Here, we show the critical role of m...
Macrophages are phenotypically plastic phagocytic cells widely distributed throughout the body and can adopt a variety of polarisation states depending on their environment15. DCs on the other hand are primarily found in tissues that interface with the external environment, such as the skin, respiratory...
Rab7 GTPase regulates mitochondrial morphology and function. Missense mutation(s) of Rab7 underlies the pathogenesis of Charcot Marie Tooth 2B (CMT2B) peripheral neuropathy. Herein, we investigate how mitochondrial morphology and function are impacted by the CMT2B associated Rab7V162M mutation. In contr...