G. The role of mitochondria in aging. J. Clin. Invest. 123:951-957; 2013.A. Bratic, N.G. Larsson, The role of mitochondria in aging, J. Clin. Investig. 123 (2013) 951-957.Bratic A, Larsson NG. The role of mitochondria in aging. J Clin Invest 2013;123: 951-7....
and medicine is addressed in this volume, including mitochondrial function and dysfunction, free radical biology relevant to mitochondrial dysfunction, the role of mitochondria in apoptosis, and abnormal signaling processes and disease mechanisms associated with aging, mtDNA mutations, or mitochondrial damage...
The role of mitochondria in aging has been shown to be crucial17,18. To ascertain whether mitochondria impairment impacts epigenetic aging, we treated HDKs with carbonyl cyanide m-chlorophenylhydrazone (CCCP), which reduces mitochondrial activity19. When JC-1 monomers were administered to control cell...
Mitochondrial dysfunction increasingly appears to be a common factor connecting several of these hallmarks, driving the aging process and afflicting tissues throughout the body. Recent research has uncovered a much more complex involvement of mitochondria in the cell than has previously been appreciated ...
and amyotrophic lateral sclerosis. Several studies have demonstrated that mitochondrial impairment plays an important role in the pathogenesis of this group of disorders. In this review, we discuss the role of mitochondria in the main neurodegenerative diseases and review the updated knowledge in this ...
G. The role of mitochondria in aging. J. Clin. Invest. 123, 951–957 (2013). Article CAS PubMed PubMed Central Google Scholar Yanos, M. E., Bennett, C. F. & Kaeberlein, M. Genome-wide RNAi longevity screens in Caenorhabditis elegans. Curr. Genomics 13, 508–518 (2012). ...
The role of alveolar epithelial cell (AEC) apoptosis by mitochondria- and p53-regulated death pathways is examined. We emphasize an emerging role for the... P Cheresh,SJ Kim,S Tulasiram,... - 《Biochimica Et Biophysica Acta》 被引量: 223发表: 2013年 Particulate Matter Induces Alveolar Epit...
Another interesting field is the role of the mitochondria and the muscle-brain axis. BURTSCHER et al. demonstrated that mitochondria in the skeletal muscle will be activated after physical exercise and secreting circulating factors including myokines, metabolites and microRNAs, which directly and indirect...
G. The role of mitochondria in aging. J. Clin. Invest. 123, 951–957 (2013). Article CAS PubMed PubMed Central Google Scholar Ebersberger, I. et al. The evolution of the ribosome biogenesis pathway from a yeast perspective. Nucleic Acids Res. 42, 1509–1523 (2014). Article CAS ...
in a number of cellular compartments, but most of the intracellular ROS can be traced back to the mitochondria.10,11There are eight sites within the mitochondrion that are known to possess the ability to generate ROS, the major source being complex 1.12,13In aging, the mitochondrial free-...