Mitochondria are unique organelles that possess a maternally inherited autonomous genome. The mitochondrial DNA (mtDNA) encodes for 13 OXPHOS proteins, in addition to 22 tRNAs and two rRNAs8(Fig.2). Due to their physical proximity to the ETC and therefore, ROS, mtDNA is highly susceptible to m...
The rate/quality of human aging and the development/progression of diseases depend on a complex interplay among genetics, epigenetics and environment. In this scenario, mitochondrial function (or dysfunction) and mitochondrial DNA have emerged as major players. This is mainly due to their crucial rol...
7月30日,南沙生命科学论坛•专题研讨会第3期——Mitochondria in Health and Disease即将线上拉开帷幕。本期研讨会将由中国科学院院士、复旦大学校长金力致辞,南开大学生命科学学院教授、院长陈佺,浙江大学“求是讲席”教授管敏鑫,清华大学生...
Aging is typified by a progressive decline in mitochondrial activity and stress resilience. Here, we review how mitochondrial stress pathways have pleiotropic effects on cellular and systemic homeostasis, which can comprise protective or detrimental responses during aging. We describe recent evidence arguing...
Since then, the accretion of knowledge in the past century has revealed much of the molecular details of mitochondria, ranging from mitochondrial origin, structure, metabolism, genetics, and signaling, and their implications in health and disease. We now know that mitochondria are remarkably ...
cell death & disease mitochondriaAtom RSS Feed Mitochondria articles within Cell Death & Disease FeaturedArticle 26 January 2025 | Open Access Synaptotagmin-1 attenuates myocardial programmed necrosis and ischemia/reperfusion injury through the mitochondrial pathway Teng Sun , Jialei Li & Jimin Cao...
Mitochondria in Health and Disease 讲座 活动时间:2019.04.08 02:00 - 2019.04.08 活动地址:金光生命科学大楼邓祐才报告厅 报名收藏清单 主办方 北京大学 讲座介绍 Mitochondria are dynamic organelles that provide cells with energy and metabolites needed for survival and growth during changes in diet, ...
and medicine is addressed in this volume, including mitochondrial function and dysfunction, free radical biology relevant to mitochondrial dysfunction, the role of mitochondria in apoptosis, and abnormal signaling processes and disease mechanisms associated with aging, mtDNA mutations, or mitochondrial damage...
Kold-Christensen, R., & Johannsen, M. (2020). Methylglyoxal Metabolism and Aging-Related Disease: Moving from Correlation toward Causation.Trends Endocrinology Metabolism,31(2), 81–92.https://doi.org/10.1016/j.tem.2019.10.003. Feb Epub 2019 Nov 19. PMID: 31757593. ...
It is therefore not surprising that mitochondrial dysfunction has emerged as a key factor in a myriad of diseases, including neurodegenerative and metabolic disorders. We provide a current view of how mitochondrial functions impinge on health and disease....