Recent studies have established an essential role of the mitochondria in skin homeostasis, as well as disorders such as cancer, inflammatory conditions, and rare inherited diseases. The mechanistic basis of mitochondrial dysfunction in the skin and other organs, is primarily ROS production and oxidative...
cell death & disease mitochondriaAtom RSS Feed Mitochondria articles within Cell Death & Disease FeaturedArticle 26 January 2025 | Open Access Synaptotagmin-1 attenuates myocardial programmed necrosis and ischemia/reperfusion injury through the mitochondrial pathway Teng Sun , Jialei Li & Jimin Cao...
It is therefore not surprising that mitochondrial dysfunction has emerged as a key factor in a myriad of diseases, including neurodegenerative and metabolic disorders. We provide a current view of how mitochondrial functions impinge on health and disease....
Aging Clinical and Experimental ResearchA.W. Linnane, Mitochondria and aging: the universality of bioenergetic disease, Aging (Milano) 4 (1992) 267-271.Linnane AW ( 1992 ): Mitochondria and aging: the universality of bioenergetic disease . Aging Clin Exp Res 4 : 267 – 271 ....
Chan DC (2006) Mitochondria: dynamic organelles in disease, aging, and development. Cell 125:1241-1252Chan DC. Mitochondria: Dynamic organelles in disease,aging, and development[J]. Cell, 2006, 125 (7):1241- 1252.CHAN D C.Mitochondria:dynamic organelles in disease, aging, and development....
Mitochondria in the Aging Heart José Marín-García Pages 273-291 Mitochondria in Atherosclerosis, Hypertension and Ischemia Front Matter Pages 293-293 Download chapterPDF 1 2 Nextpage Back to top Authors and Affiliations Neuromuscular Institute, The Molecular Cardiology and, Highland Park, USA ...
and medicine is addressed in this volume, including mitochondrial function and dysfunction, free radical biology relevant to mitochondrial dysfunction, the role of mitochondria in apoptosis, and abnormal signaling processes and disease mechanisms associated with aging, mtDNA mutations, or mitochondrial damage...
Aberrant neuronal Sigma-1 receptor (Sig-1r)-mediated endoplasmic reticulum (ER)- mitochondria signaling plays a key role in the neuronal cytopathology of Alzheimer’s disease (AD). The natural psychedelic N, N-dimethyltryptamine (DMT) is a Sig-1r agonist that may have the anti-AD potential thr...
Recently, MAM have also been studied in the context of different pathologies, including Alzheimer's disease, Parkinson’s disease, amyotrophic lateral sclerosis, type 2 diabetes mellitus and GM1-gangliosidosis. An underappreciated amount of data links MAM with aging or senescence processes. In the ...
Mitochondria are unique dynamic organelles that evolved from free-living bacteria into endosymbionts of mammalian hosts (Sagan 1967; Hatefi 1985). They have a distinct ~16.6 kb closed circular DNA genome coding for 13 polypeptides (Taanman 1999). In addi