For the second part of my talk, I will describe a second mouse model that allows for a more accurate assessment of in vivo mitophagy, namely the selective removal of damaged mitochondria. This mouse allowed us to quantify how mitophagy changes as a function of age. These results suggest that...
This symposium will discuss novel mechanistic underpinnings of cognitive decline in terms of glutathione deficiency, mitochondrial dysfunction and abnormalities in metabolism, discuss a novel intervention to reverse these defects in aging, and its applicability in AD. The symposium re will begin with a ...
Targeting glutamine metabolism in hepatic stellate cells alleviates liver fibrosis Xiaochun Yin , Jin Peng & Feng Zhang Article 22 June 2022 | Open Access Chronic inhibition of the mitochondrial ATP synthase in skeletal muscle triggers sarcoplasmic reticulum distress and tubular aggregates Cristina...
MAMs provide a platform that is fundamental for several cellular functions, such as calcium (Ca2+) homeostasis, autophagy, lipid metabolism, apoptosis, and tumor growth7,8, that allow rapid exchange of biological molecules to maintain cellular health. Therefore, the accurate connections and crosstalk ...
Miquel,et al(1980). Mitochondrial role in cell aging.Exp Gerontol, 15: 575–91. Google Scholar Chance B, Sies H, Boveris A (1979). Hydroperoxide metabolism in mammalian organs.Physiol Rev, 59: 527–605. PubMedCASGoogle Scholar Hansford RG, Hogue BA, Mildaziene V (1997). Dependence of...
Editorial Board Members3D Bioprinting Using Bioinks Containing BiomoleculesAdvanced Glycation End Products in Aging and Age-Related DiseasesAdvances in β3-AdrenoceptorAdvances in Antibody Therapy of CancerAdvances in Biomolecular Research: Selected Papers from the 2024 Biomedical Sciences SymposiumAdvances in ...
In PD, alterations in mitochondria, endoplasmic reticulum (ER), and MAM functions affect the secretion and metabolism of proteins, causing an imbalance in calcium homeostasis and oxidative stress. These changes lead to alterations in the translocation of the MAM components, such as IP3R, VDAC, ...
evolution, and more.’” (Lane p. 7) Almost everything that is known about the role of mitochondria in cellular signaling and gene expression (5),apoptosis,autophagy, metal metabolism, regulation of enzymes, and many other important functions, has been discovered since the turn of the century...
Our foundational product, MitoQ Pure, contains MitoQ® Mitoquinol, our world-first mitochondria-targeted antioxidant. Proven to get deep into cells to combat the root causes of aging and support cellular longevity, metabolism, healthier aging, and sustained energy. ...
Mitochondrial metabolism is both the basis for and target of nutrient signals that ultimately orchestrate an integrated physiological response. The molecular components that sense energy status include transcription factors, hormones, cofactors, nuclear receptors, and kinases, which detect specific signals of...