Mitochondria are unique organelles that possess a maternally inherited autonomous genome. The mitochondrial DNA (mtDNA) encodes for 13 OXPHOS proteins, in addition to 22 tRNAs and two rRNAs8(Fig.2). Due to their physical proximity to the ETC and therefore, ROS, mtDNA is highly susceptible to m...
cell death & disease mitochondriaAtom RSS Feed Mitochondria articles within Cell Death & Disease FeaturedArticle 26 January 2025 | Open Access Synaptotagmin-1 attenuates myocardial programmed necrosis and ischemia/reperfusion injury through the mitochondrial pathway Teng Sun , Jialei Li & Jimin Cao...
Mitochondrial diseases display both clinical heterogeneity and have tissue-specific manifestations, as indicated by the fact that mutations in the same mitochondrial protein complex lead to disparate disease phenotypes. For example, defects in respiratory complex I can lead to atrophy of the optic nerve...
Human mitochondria in health, disease, ageing and cancer In every human cell there are hundreds of mitochondria, which are required for oxidative phosphorylation as well as many other metabolic processes. Each mitochondrion contains approximately 5 mitochondrial DNA molecules. These circular D... E Bar...
Scheckhuber, C. Q. et al. Reducing mitochondrial fission results in increased life span and fitness of two fungal ageing models.Nat. Cell Biol.9, 99–105 (2007). ArticleCASPubMedGoogle Scholar Jiang, H.-C. et al. Neural activity and CaMKII protect mitochondria from fragmentation in agingCa...
Iron overload is a pathological condition characterized by the abnormal accumulation of iron within the body, which may result from excessive iron intake, disorders of iron metabolism, or specific disease states. This condition can lead to significant health complications and may pose life-threatening...
AgeingmtDNAtelomeresSuperoxide is generated by the mitochondrial respiratory chain. The transformation of this superoxide into hydrogen peroxide and, under certain conditions, then into hydroxyl radicals is important in diseases where respiratory chain function is abnormal or where superoxide dismutase function...
d) the role of mitophagy in neurodegeneration during health and disease, e) use of mitochondrial-directed agents to prevent dysfunction and reverse disease, f) mitochondrial tolerance to drugs and toxic agents in ageing and disease, g) the alkaloid berberine as a possible anti-cancer mitochondrial...
Mitochondria in health, disease, and aging. Physiol Rev. 2023;103:2349–422. Article CAS PubMed PubMed Central Google Scholar Mao C, Liu X, Zhang Y, Lei G, Yan Y, Lee H, et al. DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer. Nature. 2021;593:586–90. ...
During the following decades, multiple lines of evidence in model organisms and humans showed that impaired mitochondrial function can contribute to age-associated disease phenotypes and aging. However, in contrast to the original theory favoring oxidative damage as a cause for mtDNA mutations, there ...