MIR-378a位于Ppargc1b的第一内含子中,其preRNA的加工产生了两条链,miR-378a-5p和miR-378a-3p。miR-378a-3p:通常被识别为miR-378,曾被命名为miR-422b。miR-378a-5p:通常识别为miR-378*。miR-378a-3p和miR-378a-5p在线粒体丰富的组织中表达,如骨骼肌、心脏、肝脏和棕色脂肪组织(BAT),且可能参与PGC...
方法:首先使用脂多糖和干扰素γ协同诱导巨噬细胞M1极化,使用白细胞介素4诱导巨噬细胞M2极化,qRT-PCR检测各型细胞中内源性miR-378a的表达,验证miR-378a是否参与巨噬细胞的极化。通过慢病毒载体将miR-378a转染至巨噬细胞,筛选出miR...
www.nature.com/scientificreports OPEN received: 20 April 2015 accepted: 15 July 2015 Published: 10 August 2015 miR-378a-3p modulates tamoxifen sensitivity in breast cancer MCF-7 cells through targeting GOLT1A Kazuhiro Ikeda1, Kuniko Horie-Inoue1, Toshihide Ueno2, Takashi Suzuki3, ...
miR-378a, miR-378a-3p, and miR-378a-5p are encoded in thePpargc1bgene and have an active role in the regulation of several metabolic pathways such as mitochondrial metabolism and autophagy. Recent studies recognized miR-378a as an important regulator of energy and glucose homeostasis, ...
Liu et al. Stem Cell Research & Therapy (2019) 10:108 https://doi.org/10.1186/s13287-019-1216-y RESEARCH Open Access MiR-378a suppresses tenogenic differentiation and tendon repair by targeting at TGF-β2 Yang Liu1,2, Lu Feng1, Jia Xu1,3, Zhengmeng Yang1, Tianyi Wu1,3, Jiajun ...
miR-378a-3p Targets NUAK2 to Inhibit Proliferation, Migration, and Invasion of Breast Cancer Cells[J]. Cancer Research on Prevention and Treatment, 2024, 51(6): 432-439. DOI: 10.3971/j.issn.1000-8578.2024.23.1216 Citation: CHEN Jianbin, WANG Tairen. miR-378a-3p Targets NUAK2 to ...
英文别名: pCDH-CMV-MIR378A(human)-EF1-CopGFP-T2A-Puro中文名: 中文别名: CBNumber: CB313363588 分子式: 分子量: 0 MOL File: Mol file 化学性质 安全信息 用途 供应商 1 pCDH-CMV-MIR378A(human)-EF1-CopGFP-T2A-Puro化学性质 安全信息pCDH-CMV-MIR378A(human)-EF1-CopGFP-T2A-Puro性质、用途与...
Figure 4.The effect of restrained miR-378a-5p on the β-catenin protein expression in CRC cells after irradiation. (a-b) CRC cells were treated with 0 or 4 of gy irradiation, and the β-catenin protein level in the control, IC, and I groups was evaluated by Western blot. β-actin ...
Furthermore, in other mouse models of diabetes, namely, db/db mice and streptozotocin-induced diabetic mice, there was an increase and decrease in miR378a-3p expression, respectively, in line with the number of β-cells. These results suggest that miR378a-3p contained in serum extracellular ...