在此研究中,他们发现并证实在shPDCD4NPC细胞中miR-374a显著下调,且在PDCD4过表达时出现相反的影响,而c-JUN直接抑制miR-374a表达。此外还发现在PDCD4过表达的5-8FNPC细胞中,结合到miR-374a启动子上的c-JUN会显著减少。抑制miR-374a可部分恢复CCND1与pPI3K水平,同时总PI3K或PDCD4在c-JUN敲除后未出现改变。...
院 地址 100071 北京市丰台区东大街 20 号 (72)发明人 李军锋;周育森;谢柱;李浩;寇志华;陈佳唯 (74)专利代理机构 北京纪凯知识产权代理有限公司 代理人 关畅 (51)Int.CI 权利要求说明书 说明书 幅图 (54)发明名称 一种用于抑制 miR-374a 表达的 sgRNA 及其应用 (57)摘要 本发明公开了一种用于抑制 miR...
MCE 国际站:hsa-miR-374a-5p antagomir 产品活性:hsa-miR-374a-5p antagomir 是一种经过特殊化学修饰的成熟miRNA的互补单链,全链进行甲氧基修饰,在5'端和3'端分别有2个和4个硫代骨架修饰,并在3'端连接有高亲和性胆固醇修饰。miRNA antagomir通过特异性结合成熟miRNA,阻止miRNA与其靶基因的互补配对,从而抑制mi...
摘要: 目的:阐明下调miR-374a靶向转录因子21 (TCF21)调控宫颈癌细胞增殖、迁移、侵袭的分子机制.方法:采用Real-time PCR法检测微小RNA (miR)-374a在正常宫颈上皮细胞和宫颈癌细胞中的表达变化.在宫颈癌细胞SiHa中转染miR-374a inhibitor,MTT检测细胞增殖,Transwe... 查看全部>> ...
BioTNT chi-miR-374a-3p qPCR试剂盒 产品中心 >> 试剂 >> 小RNA-siRNA/干扰/miRNA >> microRNA qPCR Kits关 闭 分类:microRNA qPCR Kits 品牌:BioTNT 货号:chi-miR-374a-3p 原价:￥4030 现价:￥3098.38节省:￥931.62 规格:1 kits 说明:chi-miR-374a-3p 特异性茎环引物试剂盒 ￥615 ...
货号:mml-miR-374a-3p 原价:￥4030 现价:￥3098.38节省:￥931.62 规格:1 kits 说明:mml-miR-374a-3p 特异性茎环引物试剂盒 ￥615 产品参数 ---说明书下载--- microRNAs(miRNAs)是一类长度约19~24nt的非编码单链RNA,通过碱基互补配对的方式与靶基因的29’UTR区部分或完全互补,剪切靶基因的转录产物或者抑制...
miR-374a could target Myc, a co-transcription factor of both TGF-β1 and IL-6, to negatively regulate Myc expression; FAC stimulation significantly suppressed miR-374a expression, whereas the suppressive effect of FAC stimulation on miR-374a expression could be reversed by ROS inhibitor NAC, ...
In addition, ZEB1 was revealed to be a downstream target of miR‑374a‑5p, and overexpression of ZEB1 could reverse the anti‑apoptotic and anti‑inflammatory effects of miR‑374a‑5p on an LPS‑induced sepsis cell model. Moreover, miR‑374a‑5p‑induced protective effects ...
MiR-374a was proved to take part in the initiation and development of several cancers. However, the molecular mechanism of miR-374a in osteosarcoma (OS) ce
Collectively, miR-374a-5p exerted a protective role in sepsis-induced ALI by regulating the ZEB1-mediated p38 MAPK signaling pathway, providing a potential target for the diagnosis and treatment of sepsis. 展开 关键词: acute lung injury microRNA-374a-5p p38 MAPK signaling pathway sepsis zinc ...