目的宫颈鳞癌是女性生殖系统中最常见的恶性肿瘤,本研究探讨微RNA(microRNA,miR)-9-5p对宫颈鳞癌细胞迁移,侵袭能力及上皮间质转化(epithelial-mesenchymal transition,EMT)进程的影响.方法利用生物信息学网站预测能与E-钙黏蛋白(E-cadherin,E-cad)靶向结合的miRs;利用癌症基因组图谱(The Cancer Genome Atlas,TCGA)数据...
【关键词】 miR一9—5p;FOX01基因;食管癌细胞;增殖;侵袭;迁移中图分类号:R735.1 文献标识码:A 文章编号:1006—5709(2019)06—0644—06 收稿日期:2019-01.10miR-9-5p regulates proliferation,invasion and migration of esophageal cancer cellsby targeting FOX01 geneSHI Junli,WANG Lei,WANG Chunqing,LI ...
The most common malignant type of kidney cancer is clear cell renal cell carcinoma (ccRCC). The expression levels of hyaluronan-mediated motility receptor (HMMR) in many tumor types are significantly elevated. HMMR is closely associated with tumor-related progression, treatment resistance, and poor ...
miR-9-5p靶向FGF9抑制胃癌细胞迁移侵袭的作用机制 ｍｉＲ－９－５ｐ靶向ＦＧＦ９抑制胃癌细胞迁移侵袭的作用机制 苏 静，薛凌飞，张晓彤，田春桃 ＴｈｅｅｆｆｅｃｔｏｆｍｉＲ－９－５ｐｏｎｔｈｅｍｉｇｒａｔｉｏｎａｎｄｉｎｖａｓｉｏｎｏｆｇａｓｔｒｉｃｃａｎｃｅｒｃｅｌｌｓｂｙｔａｒｇｅ ｔｉｎｇＦＧＦ９ Ｓｕ...
miR-9-5p靶向leptin促进家兔前体脂肪细胞分化 摘要 microRNA是一种内源性短链非编码小RNA，其长度一般在22-24 nt。研究表明microRNA在脂肪细胞分化和脂肪代谢中发挥着重要作用。miR-9-5p调控了多种癌细胞、肝细胞和纤维细胞的分化与增殖过程，但miR-9-5p对脂肪细胞分化的调控仍未见相关报道。LEPTIN通过介导AMPK和...
In the cancer microenvironment, the cancer cell-secreted exosomes and microRNAs (miRNAs) can be internalized by other cells, shuttled in the exosomes, and delivered to the recipient cells to mediate gene expression [12]. Accumulating evidence has ascertained the functionality of miRNAs as critical ...
2.Active FOXO1 Is a Key Determinant of Isoform-Specific Progesterone Receptor Transactivation and Senescence Programming[J].Diep;Caroline H.;Lange;Carol A.;Knutson;Todd P.,Molecular cancer research: MCR.2016,第2期 3.Analysis of salivary microRNA expression profiles and identification ...
Long noncoding RNAs (lncRNAs) are abnormally expressed in many malignant tumors and involved in regulating the malignant phenotypes of cancer cells. However, the role of LINC00665 in colorectal cancer (CRC) and its regulatory mechanism remain unclear. In this study, real-time polymerase chain react...
LncRNA MEG3 was a down‐regulated lncRNA in prostate cancer and impacted the abilities of cell proliferation, migration and invasion, and cell apoptosis rate, this regulation relied on regulating miR‐9‐5p and its targeting gene QKI‐5.Meng...
Abstract:【Objective】 To study the effect of microRNA-96-5p (miR-96-5p) on the proliferation and invasion of endometrial cancer cells by targeting forkhead box transcription factor O1 (FOXO1) genes.【Methods】 The express...