目的宫颈鳞癌是女性生殖系统中最常见的恶性肿瘤,本研究探讨微RNA(microRNA,miR)-9-5p对宫颈鳞癌细胞迁移,侵袭能力及上皮间质转化(epithelial-mesenchymal transition,EMT)进程的影响.方法利用生物信息学网站预测能与E-钙黏蛋白(E-cadherin,E-cad)靶向结合的miRs;利用癌症基因组图谱(The Cancer Genome Atlas,TCGA)数据...
【关键词】 miR一9—5p;FOX01基因;食管癌细胞;增殖;侵袭;迁移中图分类号:R735.1 文献标识码:A 文章编号:1006—5709(2019)06—0644—06 收稿日期:2019-01.10miR-9-5p regulates proliferation,invasion and migration of esophageal cancer cellsby targeting FOX01 geneSHI Junli,WANG Lei,WANG Chunqing,LI ...
miR-9-5p靶向FGF9抑制胃癌细胞迁移侵袭的作用机制 ｍｉＲ－９－５ｐ靶向ＦＧＦ９抑制胃癌细胞迁移侵袭的作用机制 苏 静，薛凌飞，张晓彤，田春桃 ＴｈｅｅｆｆｅｃｔｏｆｍｉＲ－９－５ｐｏｎｔｈｅｍｉｇｒａｔｉｏｎａｎｄｉｎｖａｓｉｏｎｏｆｇａｓｔｒｉｃｃａｎｃｅｒｃｅｌｌｓｂｙｔａｒｇｅ ｔｉｎｇＦＧＦ９ Ｓｕ...
In the cancer microenvironment, the cancer cell-secreted exosomes and microRNAs (miRNAs) can be internalized by other cells, shuttled in the exosomes, and delivered to the recipient cells to mediate gene expression [12]. Accumulating evidence has ascertained the functionality of miRNAs as critical ...
Objective: To analyze the effect of expression of microRNA-17-5p (miR-17-5p) in the colorectal cancer cell-derived exosomes (Exo) on the chemotherapy sensi... 刘珊,邢兆东,黄平 - 《Journal of Jilin University:medicine Edition》 被引量: 0发表: 2023年 血浆外泌体miR-145-5p在颅内动脉瘤患者...
Long noncoding RNAs (lncRNAs) are abnormally expressed in many malignant tumors and involved in regulating the malignant phenotypes of cancer cells. However, the role of LINC00665 in colorectal cancer (CRC) and its regulatory mechanism remain unclear. In this study, real-time polymerase chain react...
Most of the miRNAs analyzed are potentially involved in cancer, either specific types such as hepatocellular carcinoma (miR-9-5p), renal cell carcinoma (miR-1-3p), and thyroid cancer (miR-1-3p), or specific processes associated with cancer (miR-9-5p, miR-21-5p, miR-124-3p, and miR-...
Since our results have shown that miR-9 inhibits MC3T3-E1 cell proliferation, these results indicate that miR-9 inhibits cell proliferation not only in bone cells, but also in cancer cells, thus providing potential therapeutic targets and novel prognostic biomarkers. miR-675 was upregulated in ...
LncRNA MEG3 was a down‐regulated lncRNA in prostate cancer tissues and cells and could inhibit the expression of miR‐9‐5p, whereas miR‐9‐5p down‐regulated QKI‐5 expression. Overexpressed MEG3 and QKI‐5 could decrease the abilities of proliferation, migration and invasion in prostate ...
Abstract:【Objective】 To study the effect of microRNA-96-5p (miR-96-5p) on the proliferation and invasion of endometrial cancer cells by targeting forkhead box transcription factor O1 (FOXO1) genes.【Methods】 The express...