miR-9-5p和REST之间显著负相关,miR-9-5p模拟物和RESTmiRNA转染后可显著逆转由IL-6和TNF-α引起的细胞活力的下降和细胞凋亡的增加。此外,miR-9-5p的过表达可以上调miR-132,靶向E1A结合蛋白EP300(EEP300),磷酸酶和张力蛋白同源物(PTEN)和FOXO3的miRNA的表达。这些结果表明,炎症损伤时miR-9-5p通过靶向REST / m...
此外,CM-EV来源的miR-9-5p被鉴定为诱导中性粒细胞产生N1表型的介质。机制上,miR-9-5p直接抑制SOCS5和SIRT1的表达,从而激活中性粒细胞中的JAK2/STAT3和NF-κB信号通路。重要的是,本研究证实血清EV来源的miR-9-5p水平与接受经皮冠状动脉介入治疗的ST段抬高型心肌梗死患者的心血管死亡率独立相关。这些发现表明中性...
miR-9-5p is enriched in the brain tissues and plays a role in the pathological process of IS. Therefore, the purpose of this study is to explore the effect of miR-9 on ER stress and underlying mechanism in IS. Here, a middle cerebral artery occlusion (MCAO) rat model was utilized to...
总而言之,此项研究通过在败血症体内外模型中阻断miR-9-5p诱导的SIRT1沉默,为TUG1对巨噬细胞极化及其抗炎效力的贡献提供了证据,为靶向EPC来源的EVs分泌的TUG1用于临床治疗败血症提供了一种潜在策略。 图TUG1/miR-9-5p/SIRT1信号通路在败血症巨噬细胞极化调节中的功能作用示意图。TUG1在脓毒症中下调,其可削弱miR...
摘要：目的 观察微小RNA （miR ）-9-5p 对肺腺癌细胞增殖和侵袭迁移能力的调控作用，并基于痉挛性截瘫20 （SPG20）基因及Notch 信号通路探讨相关机制。方法 培养肺腺癌细胞株A549并分为抑制物组、阴性对照组和未转染组，抑制物组和阴性对照组分别转染miR -9-5p 抑制物和阴性对照，未转染组不进行转染；采用MTT ...
MCE 国际站:hsa-miR-9-5p antagomir 产品活性:hsa-miR-9-5p antagomir 是一种经过特殊化学修饰的成熟miRNA的互补单链,全链进行甲氧基修饰,在5'端和3'端分别有2个和4个硫代骨架修饰,并在3'端连接有高亲和性胆固醇修饰。miRNA antagomir通过特异性结合成熟miRNA,阻止miRNA与其靶基因的互补配对,从而抑制miRNA的...
miR-9-5p 过表达组在处理24h和48h后的细胞活力显著高于对照组，差异有统计学意义(P<0.05)；而miR-9-5p抑制剂组与对照组比较，细胞活力在24h和48h出现明显下降，差异有统计学意义(P<0.05)。miR-9-5p过表达组的肿瘤体积和湿重显著高于对照组，差异有统计学意义(P<0.05)。miR-9-5p过表达组的UBE4B的...
were affected by the expression of miR-9-5p. Collectively, these results demonstrate that miR-9-5p promotes MSC migration by upregulating β-catenin signaling pathway, shedding light on the optimization of MSCs for cell replacement therapy through manipulating the expression level of miR-9-5p. ...
Erratum to: MiR-9-5p Down-Regulates PiT2, but not PiT1 in Human Embryonic Kidney 293 CellsPiT2miR-9HEK293 cellsInorganic phosphate (Pi) is an essential component for structure and metabolism. PiT1 (SLC20A1) and PiT2 (SLC20A2) are members of the mammalian type-III inorganic phosphate ...
This study provides supportive evidence that miR-9-5p, miR-124-3p, and miR-132-3p play a role in TSC-AMLs through the regulation of BCL2L11.doi:10.1038/s41374-018-0051-6Cai, YiWang, WendaGuo, HaoLi, HanzhongXiao, YuZhang, Yushi...