Bladder cancerHK2MiR-125b-5pPI3K/AKT pathwayBladder cancer (BCa) is identified as the most common malignant solid cancer in the urogenital tract. Recently, dysregulation of miRNAs has received more attention because of its extensive role in the carcinogenesis of BCa. This research was designed to...
Chen F, He H, Li H, Chen X. MiR-125b-5p modulates the function of regulatory T cells in tumor microenvironment by targeting TNFR2. J Immunother Cancer. 2022 Nov;10(11):e005241. doi: 10.1136/jitc-2022-005241.
miR-125b-5p/TPD52 axis affects proliferation, migration and invasion of breast cancer cells[J]. Mol Biotechnol, 2022, 64(9): 1003-12. [10]Wen Z, Huang G, Lai Y, et al. Diagnostic panel of serum miR-125b- 5p, miR-182- 5p, and miR- 200c- 3p as non- invasive biomarkers for ...
肺癌是一个全球性的恶性肿瘤,它的患病率和死亡率都很高.其中,非小细胞肺癌患病率(non-small cell lung cancer,NSCLC)占到了肺癌总体患病率的85%.现阶段,顺铂(cisplatin,DDP)仍是大多数NSCLC晚期患者和术后患者的一线化疗药物,但其存在着固有性的和获得性的化疗耐药,从而导致患者治疗失败,预后不良.因此,克服顺铂化...
Gallbladder cancer represents the most common malignancy of the biliary tract and is highly lethal with less than 5% overall 5-year survival rate. Chemotherapy remains the major treatment for late-stage patients. However, insensitivity to these chemother
Successful/effective cancer therapy in low grade lymphoma is often hampered by cell resistance to anti-neoplastic agents. The crucial mechanisms responsible for this phenomenon are poorly understood. Overcoming resistance of tumor cells to anticancer agents, such as proteasome inhibitors, could improve th...
miR-125b-5p up-regulation promoted cell death in gallbladder cancer cells in the presence of cisplatin. In contrast, knockdown of miR-125b-5p reduced cell death in gallbladder cancer cells treated with cisplatin. Up-regulation of miR-125b-5p significantly decreased tumor growth in combination ...
亡基因的表达,增强MDS细胞的增殖活性,而Cancer,2022,13(3):918-931. STAT3的3′-UTR区域存在miR-125b-5p的结合位 [6]BENTONCB,KHANM,SALLMAND,etal.Prognosisofpa⁃ tientswithintermediateriskIPSS-Rmyelodysplasticsyndromein⁃ [13] 点,miR-125b-5p可通过抑制JAK2/STAT3信号通 路,从而抑制MDS的发生、发...
MicroRNAs (miRNAs) play important roles in the progression of human cancer including esophageal squamous cell carcinoma (ESCC). Although previous reports showed that miR-125b-5p was down-regulated in ESCC, the roles and mechanisms of loss of function of miR-125b-5p in ESCC were still unknown....
Moreover, circ_RPPH1/miR-146b-3p/E2F2 axis could promote the progression of breast cancer and circCUL2/miR-214-5p/E2F2 axis-suppressed retinoblastoma cells [46,47]. When analysing the effect of miRNAs expression on E2F2 gene expression and E2F2 protein concentration, we observed no ...