5-FUResistancemiR-193b-5pHMGA2MAPKThe emergence of chemoresistance to 5-fluorouracil (5-FU)-based chemotherapy is the main cause of treatment failure in advanced and metastatic colorectal cancer (CRC) patients. Long noncoding RNAs (lncRNAs) have been reported to be involved in 5-FU resistance....
MiR-193b-3p is well-known for its tumorigenic effect, but there are few studies on miR-193b-5p, and its role in tongue cancer has not been reported. Methods:In the present research, we investigated the specific role of miR-193b-5p in tongue cancer. MiR-193b-5p mimics were ...
For example, one abundant circHIPK3, which regulates cell growth in cancerous tissues, acts as miRNA sponges to inhibit miR-124 activity by directly binding to miR-12424. The exon-intron circular RNAs circEIF3J and circPAIP2 interact with U1 snRNP and enhance transcription of their parental ...
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In concordance with these results, miR-193a belonging to the same miRNA family as miR-193b has also been shown to directly target MCL1 mRNA in the context of dexamethasone-resistant MM cell lines [36] and colorectal cancer [37]. Furthermore, we observed that transfection of the miR-193b ...