目的宫颈鳞癌是女性生殖系统中最常见的恶性肿瘤,本研究探讨微RNA(microRNA,miR)-9-5p对宫颈鳞癌细胞迁移,侵袭能力及上皮间质转化(epithelial-mesenchymal transition,EMT)进程的影响.方法利用生物信息学网站预测能与E-钙黏蛋白(E-cadherin,E-cad)靶向结合的miRs;利用癌症基因组图谱(The Cancer Genome Atlas,TCGA)数据...
Studies have shown that miR-9-5p facilitated the growth and migration of non-small cell lung cancer cells by downregulating TGFBR2 [26]; it could also inhibit PDK4 to modulate the physiological function of mitochondria in hepatocellular carcinoma (HCC) cells, illustrating its regulatory role in ...
如ZHENG等研究发现miR-590-5p在胃癌患者血浆外泌体中呈低表达,且其低表达与患者总生存率降低显著相关,可作为早期诊断标志物及预后评估的独立预测因子。WU等研究显示,miR-1290在肺腺癌患者血清外泌体中的表达较健康对照组显著上调,miR-1290高表达...
miR-9-5p靶向FGF9抑制胃癌细胞迁移侵袭的作用机制 ｍｉＲ－９－５ｐ靶向ＦＧＦ９抑制胃癌细胞迁移侵袭的作用机制 苏 静，薛凌飞，张晓彤，田春桃 ＴｈｅｅｆｆｅｃｔｏｆｍｉＲ－９－５ｐｏｎｔｈｅｍｉｇｒａｔｉｏｎａｎｄｉｎｖａｓｉｏｎｏｆｇａｓｔｒｉｃｃａｎｃｅｒｃｅｌｌｓｂｙｔａｒｇｅ ｔｉｎｇＦＧＦ９ Ｓｕ...
LEPTIN通过介导AMPK和JAK/STAT信号通路调控脂类代谢，且LEPTIN是miR-9-5p的一个潜在的靶基因，故推测miR-9-5p对前体脂肪细胞的分化有影响。本实验以刚出生新西兰白兔的脂肪组织为材料分离培养前体脂肪细胞，通过人工合成miR-9-5P类似物转染前体脂肪细胞后诱导分化，然后检测相关基因mRNA的水平。随后试验构建了pis-CHECH-...
[12]Wang G, Zhou Y, Chen W, et al. miR-21-5p promotes lung adenocarcinoma cell proliferation, migration and invasion via targeting WWC2[J]. Cancer Biomark, 2020, 28(4): 549-559. DOI:10.3233/CBM-201489 [13]Zhou LY, Zhang FW, ...
目的 探究LncRNA LINC00665通过miR-9-5p调节转录激活因子(ATF)1表达,促进甲状腺乳头状癌(PTC)的进展.方法 收集手术切除的PTC组织及癌旁组织80例,qRT-聚合酶链反应(PCR... 赵爱兵,马丽华,窦国章,... - 《中国老年学杂志》 被引量: 0发表: 2024年 LncRNA LINC00665 Promotes Ovarian Cancer Cell Proliferatio...
MicroRNAs (miRNAs) were reported to be associated with cancer progression and carcinogenesis. MiRNAs are small, highly conserved, small non-coding RNA mole
［Key words］miR-95-5p；SATB1；Non-small cell lung cancer；Proliferation；β-catenin 肺癌是最常见的致死癌症种类之一，全球每年大约新增140万肺癌新病例［1-2］。两种主要的肺癌亚型是小细胞肺癌（small cell lung cancer，SCLC）和非小细胞肺癌（non-small cell lung cancer，NSCLC），二者比例分别为15％~20...
Immunohistochemical staining was also used to investigate on how miR-199a-5p regulates the tumour-suppressive effects of klotho in gastric cancer. Results In our present study, we found that miR-199a-5p level was significantly increased in gastric cancer tissues compared to paired normal tissues. ...