In conclusion, miR-432-5p inhibits the ferroptosis in cardiomyocytes induced by H/R by activating Nrf2/SLC7A11 axis by degrading Keap1 and is a potential drug target for clinical myocardial infarction treatment.Geng, WeiYan, ShaohuaLi, Xinyue...
et al. Cancer associated fibroblast secreted miR-432-5p targets CHAC1 to inhibit ferroptosis and promote acquired chemoresistance in prostate cancer. Oncogene 43, 2104–2114 (2024). https://doi.org/10.1038/s41388-024-03057-6 Download citation Received24 August 2023 Revised27 April 2024 Accepted30...
目的探讨石见穿多糖对宫颈癌细胞增殖和凋亡的影响及可能的机制.方法体外培养宫颈癌SiHa细胞,用不同剂量的石见穿多糖(0.125mg/mL,0.250mg/mL,0.500mg/mL)干预24h后,采用CCK-8法和克隆形成实验检测细胞增殖,流式细胞术检测细胞凋亡,实时荧光定量聚合酶链反应(qRT-PCR)法检测circ-PRMT5和miR-432-5p的表达.双荧光...
RETRACTED ARTICLE: Knockdown of CircCRIM1 Inhibits HDAC4 to Impede Osteosarcoma Proliferation, Migration, and Invasion and Facilitate Autophagy by Targeting miR-432-5p Jun Liu, Guang Feng, Zhengwei Li, Rui Li & Peng Xia Pages 10199-10210 | Published online: 15 Oct 2020 Cite this article Cross...
RETRACTED ARTICLE: Knockdown of CircCRIM1 Inhibits HDAC4 to Impede Osteosarcoma Proliferation, Migration, and Invasion and Facilitate Autophagy by Targeting miR-432-5p Jun Liu, Guang Feng, Zhengwei Li, Rui Li & Peng Xia Pages 10199-10210 | Published online: 15 Oct 2020 Cite this article Cross...
The levels of miR-432-5p and Sortilin 1 (SORT1) in the serum of CAD patients and oxidized low-density lipoprotein (ox-LDL)-treated human arterial smooth muscle cells (HASMCs) were quantified via qRT-PCR. The correlation coefficient, clinical diagnostic performance, and risk factors were ...
非小细胞肺癌miR-432-5p细胞增殖迁移侵袭非小细胞肺癌(Non-small cell lung cancer,NSCLC)约占所有肺癌病例的80%-85%,而腺癌是NSCLC最常见的类型.尽管近年肿瘤治疗手段已经取得较大进展,但由于肿瘤耐药,复发和转移等问题,肺癌患者死亡率仍高居不下[1].李丽秋高倩顾玲李志辉王进许微张雄飞张旭陈美娟中国药理学通报...
Furthermore, miR-432-5p knockdown reversed circ_0000395 silencing-mediated effects on CRC cell malignant phenotypes. MYH9 overexpression counteracted the inhibiting effects of miR-432-5p upregulation on CRC cell malignant phenotypes. Additionally, CRC cells derived from exosomal ci...
miR-432-5p inhibitor竞争性结合miR-432-5p显著上调胃癌细胞中BMP5蛋白表达(P<0.05),并明显抑制胃癌细胞增殖,迁移和侵袭(P<0.05),而同时使用BMP5特异性小干扰RNA(siRNA)沉默BMP5则明显逆转这一作用(P<0.05);双荧光素酶报告基因实验证实miR-432-5p能靶向结合BMP5 mRNA的3′UTR区.结论 在GC组织中miR-432-5p...
Our study found that miR-432-5p, originating from cancer-associated fibroblast (CAF) exosomes, suppresses ferroptosis by targeting CHAC1, thereby increasing resistance to docetaxel (DTX) in PCa. This research introduces a novel approach to address resistance to DTX....