当SNHG16过表达时,miR-432-5p水平下降42%,同时胶原蛋白I型(Col I)、Runt相关转录因子2(RUNX2)和骨钙素(OCN)等成骨标志物表达显著上调。 研究还揭示了临床转化价值:多因素Logistic回归显示,SNHG16是骨折延迟愈合的独立保护因素(OR=0.225)。这意味着检测血清SNHG16水平不仅有助于OPF诊断,还能预测愈合预后。在...
Furthermore, miR-432-5p was identified to diminish glutathione (GSH) consumption by targeting CHAC1, consequently inhibiting ferroptosis in prostate cancer cells. Our study found that miR-432-5p, originating from cancer-associated fibroblast (CAF) exosomes, suppresses ferroptosis by targeting CHAC1, ...