目的探讨血浆微小RNA-424(MicroRNA,miR-424),成纤维细胞生长因子2(Fibroblast growth factor 2,FGF2)水平与急性缺血性脑卒中(Acute ischemic stroke, AIS)患者血管介入术后出血转化(Hemorrhagic transformation, HT)的相关性.方法选取2018年12月-2020年3月本院收治的AIS患者104例为研究对象,均行脑部血管机械取栓,...
4. High Levels of Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 in Acute Stroke: An Age- and Sex-Matched Cross-Sectional Study.[J].Chiaki; Yokota;Tatsuya; Sawamura;Makoto; Watanabe;Yoshihiro; Kokubo;Yoshiko; Fujita;Akemi; Kakino;Michikazu; Nakai;Kazunori; Toyoda;Yoshihiro; M...
Global DNA and histone methylation patterns in astrocytes following ischemia are influenced by age; however, it is unknown whether aberrant methylation can induce reactive astrogliosis after ischemic stroke in elderly rodents. Here we showed that phosphorylated signal transducer and activator of transcription...
Reduced availability of oxygen can occur in physiological conditions such as wound healing and physical exertion as well as pathological situations such as stroke and myocardial ischemia. A complex adaptation system centered around hypoxia-inducible factor (HIF) is responsible for restoring oxygen and nut...
(email: zxnong@hotmail.com) SCIenTIFIC RepOrts | 7:42331 | DOI: 10.1038/srep42331 1 www.nature.com/scientificreports/ evidence demonstrates that miR-424 is downregulated by oxidative stress in patients and mice after ischaemic stroke8,9. Based on these observations, we hypothesized that the ...
Cell culture and rodent studies suggest that miR-424 could help treat cardiovascular diseases such as myocardial infarction and stroke. Further details on the research, next steps and licensing status are discussed in the article.SciBX: Science-Business eXchangedoi:10.1038/scibx.2010.1288None...
ischemic strokemiR‐424NFIAreactive astrogliosisGlobal DNA and histone methylation patterns in astrocytes following ischemia are influenced by age; however, it is unknown whether aberrant methylation can induce reactive astrogliosis after ischemic stroke in elderly rodents. Here we showed that phosphorylated ...
MiR-424 prevents astrogliosis after cerebral ischemia/reperfusion in elderly mice by enhancing repressive H3K27me3 via NFIA/DNMT1 signalingDNMT1H3K27me3ischemic strokemiR-424NFIAreactive astrogliosisdoi:10.1111/febs.15029Haiping ZhaoGuangwen Li