目的探讨血浆微小RNA-424(MicroRNA,miR-424),成纤维细胞生长因子2(Fibroblast growth factor 2,FGF2)水平与急性缺血性脑卒中(Acute ischemic stroke, AIS)患者血管介入术后出血转化(Hemorrhagic transformation, HT)的相关性.方法选取2018年12月-2020年3月本院收治的AIS患者
目的 观察急性脑梗死(ACI)患者血清循环微小RNA-424(miR-424)的表达变化,并分析其与炎症反应、脂代谢的关系.方法 100例ACI患者根据NIHSS评分分为重度ACI61例、轻度ACI39例,60例健康体检者为对照.采集纳入者空腹静脉血,采用实时定量PCR法检测血清循环miR-424,采用ELISA法检测血清炎症反应因子白细胞介素-6(IL-6)...
Hypoxia and ischemia Reduced availability of oxygen can occur in physiological conditions such as wound healing and physical exertion as well as pathological situations such as stroke and myo- cardial ischemia. A complex adaptation system centered around hypoxia-inducible factor (HIF) is responsible ...
Stroke 44, 1706–1713 (2013). 27. Rosa, A. et al. The interplay between the master transcription factor PU.1 and miR-424 regulates human monocyte/macrophage differentiation. Proc Natl Acad Sci U S A 104, 19849–19854 (2007). 28. Oishi, T. et al. Osteogenic differentiation capacity of...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal human cancers. It thrives in a malnourished environment; however, little is known about the mechanisms by which PDAC cells actively promote aerobic glycolysis to maintain their metabolic needs. Gene Expression Omnibus (GEO) wa...
In pre-clinical models, ECFCs are reported to enhance the patency of implanted vascular grafts and to improve outcomes in ischemic diseases, such as stroke, myocardial infarction and limb ischemia20–31. Given their ability to proliferate, migrate, incorporate into vascular networks, release ...
Bioinformatics analysis and in vivo validation of ferroptosis-related genes in ischemic stroke 2022, Frontiers in Pharmacology Show abstract From circRNAs to fusion circRNAs in hematological malignancies 2021, JCI Insight Show abstract The functions and clinical significance of circRNAs in hematological malign...
22.Li G, Ma Q, Wang R, Fan Z, Tao Z, Liu P, Zhao H, Luo Y. Diagnostic and immunosuppressive potential of elevated Mir-424 levels in circulating immune cells of ischemic stroke patients. Aging Dis. 2018; 9:172–81.https://doi.org/10.14336/AD.2017.0602[PubMed] ...
In severe cases, it may increase the risk of coronary heart disease, stroke, and diabetes [1]. Ultrasonic scaling is commonly used clinically to remove dental calculus and plaque, and anti-inflammatory drugs are primarily used for treatment. Surgery is required in severe cases; however, the ...
MiR-126 has been found to have a protective role in metabolic and neurological diseases, such as diabetes, ischemic stroke, and Parkinson’s disease. However, excessive levels of this molecule may also make individuals more vulnerable to viral myocarditis [82,83]. The multifaceted nature of miR...