目的 观察急性脑梗死(ACI)患者血清循环微小RNA-424(miR-424)的表达变化,并分析其与炎症反应、脂代谢的关系.方法 100例ACI患者根据NIHSS评分分为重度ACI61例、轻度ACI39例,60例健康体检者为对照.采集纳入者空腹静脉血,采用实时定量PCR法检测血清循环miR-424,采用ELISA法检测血清炎症反应因子白细胞介素-6(IL-6)、...
Hypoxia and ischemia Reduced availability of oxygen can occur in physiological conditions such as wound healing and physical exertion as well as pathological situations such as stroke and myo- cardial ischemia. A complex adaptation system centered around hypoxia-inducible factor (HIF) is responsible ...
(email: zxnong@hotmail.com) SCIenTIFIC RepOrts | 7:42331 | DOI: 10.1038/srep42331 1 www.nature.com/scientificreports/ evidence demonstrates that miR-424 is downregulated by oxidative stress in patients and mice after ischaemic stroke8,9. Based on these observations, we hypothesized that the ...
Stroke 44, 1706–1713 (2013). 27. Rosa, A. et al. The interplay between the master transcription factor PU.1 and miR-424 regulates human monocyte/macrophage differentiation. Proc Natl Acad Sci U S A 104, 19849–19854 (2007). 28. Oishi, T. et al. Osteogenic differentiation capacity of...
22.Li G, Ma Q, Wang R, Fan Z, Tao Z, Liu P, Zhao H, Luo Y. Diagnostic and immunosuppressive potential of elevated Mir-424 levels in circulating immune cells of ischemic stroke patients. Aging Dis. 2018; 9:172–81.https://doi.org/10.14336/AD.2017.0602[PubMed] ...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal human cancers. It thrives in a malnourished environment; however, little is known about the mechanisms by which PDAC cells actively promote aerobic glycolysis to maintain their metabolic needs. Gene Expression Omnibus (GEO) wa...
32,No. 9 35 缺血性卒中( ischemic stroke) 是指脑缺血缺氧 导致脑组织损伤,进而产生神经功能缺损的一类疾 病,其主要原因为脑供血动脉狭窄或闭塞. 缺血性 卒中是全球致死和残疾的第二大原因[1] . 小胶质 细胞( microglial) 作为大脑的巨噬细胞,可以监测微 环境并启动免疫应答. 在对各种脑损伤的反应中, 小...
Yang et al. reported that the circRNA circPHKA2 was downregulated in the blood of acute ischemic stroke patients, as was superoxide dismutase 2 (SOD2) [94]. Mechanistically, circPHKA2 was found to target miR-574-5p to upregulate SOD2 expression. circPHKA2 was therefore suggested to protect...
Micro-RNA-30a regulates ischemia-induced cell death by targeting heat shock protein HSPA5 in primary cultured cortical neurons and mouse brain after stroke. J Neurosci Res 93, 1756–1768, doi:10.1002/jnr.23637 (2015). Article CAS PubMed Google Scholar Pan, W. et al. MiR-30-regulated ...
Glioblastoma (GBM) is the most prevalent primary cerebral tumor in adults with high aggressiveness. Temozolomide (TMZ) is considered as the most widely use