Regulation of miR-483-3p by the O-linked N-acetylglucosamine transferase links chemosensitivity to glucose metabolism in liver cancer cells[J]. Oncogenesis, 2017, 6 (5): e328. [10]Xiao S, Yang MY, Yang H, et al. miR-330-5p targets SPRY2 to promote hepatocellular carcinoma progression ...
因此,miR-424-5p可以用于制备抑制转移性肝癌的药物. Thus, miR-424-5p can be used to prepare a drug to inhibit metastatic liver cancer.韩丽辉张颖李涛赵伟魏清怀婉婉郭蓬勃
Zhang et al had demonstrated that miR-424-5p expression was significantly reduced in the liver cancer tissues compared with that of the corresponding non-cancerous liver tissues and down regulation of miR-424-5p in HCC tissues was also related to advanced disease progression in HCC patients [12...
目的 研究宫颈脱落细胞中微小RNA-424(miR-424)和枯灵素2(CUL2)信使RNA(mRNA)表达水平对宫颈人乳头瘤病毒(HPV)16持续感染的预测价值.方法 选取2020年1月至2021年11月在邯郸市中心医院宫颈液基细胞学检查正常的259例宫颈HPV16感染者为研究对象,随访1年后复查,HPV16仍是阳性者归为HPV16持续感染组(136例),HPV16转为...
reported miR-424-5p as a tumor suppressive microRNA to regulate basal-like breast cancer proliferation, migration and invasion[7]. However, miR-424-5p is reported to up-regulate in colon cancer[8] and pancreatic carcinoma[9]. It is also reported that miR-424-5p is up-regulated in gastric...
Meta-analysis shows that women with diabetes have a 20% increased risk of breast cancer and also an increased risk for distant metastasis and mortality. The molecular mechanisms for distant metastasis and mortality in breast cancer patients with diabetes
Non-coding RNAs (ncRNAs) have been shown to regulate gene expression involved in tumor progression of multiple malignancies. Our previous studies indicated that large tumor suppressor kinase 1 (LATS1), a core part of Hippo signaling pathway, functions as a tumor suppressor in gastric cancer (GC)...
In pancreatic cancer, BCL9L knockdown decreases cell proliferation, migration, invasion, and liver metastasis, and increases E-cadherin expression even in the presence of TGF-β, suggesting a role of BCL9L in regulating EMT31. These results supported our data that downregulation of BCL9L ...
[18,19]. Moreover,in vitroandin vivostudies proved that local anesthetics might also have direct effects on certain tumor cells, including non-small cell lung cancer [20], hepatocarcinoma cells [21], and thyroid cancer cells [22]. Recently, Li et al. implied that exposure to ropivacaine ...
Background: Liver cancer is a major public health concern, but the mechanistic actions of bio-markers contributing to liver cancer remain to be determined. In this study, we aimed to investigate the regulatory cascade of microRNA-424-5p (miR-424-5p), X-inactive-specific transcript (XIST), ...