In addition, ZEB1 was revealed to be a downstream target of miR‑374a‑5p, and overexpression of ZEB1 could reverse the anti‑apoptotic and anti‑inflammatory effects of miR‑374a‑5p on an LPS‑induced sepsis cell model. Moreover, miR‑374a‑5p‑induced protective effects ...
Collectively, miR-374a-5p exerted a protective role in sepsis-induced ALI by regulating the ZEB1-mediated p38 MAPK signaling pathway, providing a potential target for the diagnosis and treatment of sepsis. 展开 关键词: acute lung injury microRNA-374a-5p p38 MAPK signaling pathway sepsis zinc ...
miR-374a-5p was also found to directly target arrestin beta 1 (ARRB1) that is specifically downregulated in TNBC patients in several human genomic datasets. Overexpressed ARRB1 reduced TNBC cell growth and migration, and the ARRB1 expression level is inversely correlated with the histological ...
miR-374a-5p bound to Neurod1 to antagonize its effect on chemoresistance. Exosome-mediated delivery of miR-374a-5p inhibitor could increase Neurod1 expression, promote cell apoptosis, and suppress chemoresistance. miR-374a-5p had a promoting role in gastric cancer chemoresistance, which would ...
miR-374a-5p expression and localization in intracranial aneurysm (IA) tissues were detected, and its correlation with vascular smooth muscle cells (VSMCs) and macrophage markers was analyzed. Using platelet-derived growth factor-BB (PDGF-BB) induced VSMC model, elastase-induced IA rat model. Su...
374b-5p的表达水平均较空白对照组和阴性对照组明显下调(P < 0.05).荧光素酶报告载体系统证实,RECK是miR-374b-5p直接调控的靶基因;miR-374b-5p抑制组移植瘤中RECK mRNA及蛋白的表达水平均显著高于空白对照组和阴性对照组(P均<0.05).结论:miR-374b-5p可能通过RECK通路在胃癌的发生和发展中扮演着癌基因的角色....
The present study aimed to evaluate the biological roles of miR374a5p in NSCLC. Using reverse transcriptionquantitative PCR, the expression levels of miR374a5p were determined in NSCLC cells and a normal cell line. Functional experiments were performed to investigate the functions of miR374a5p ...
However, it is not clear whether miR-374a-5p could be delivered to renal cells by exosomes and exerts anti-renal fibrosis effects. To mimic renal fibrosis 展开 关键词: MAPK6 Renal fibrosis exosomes mesenchymal stem cells (MSC) miR-374a-5p ...