其中Csf1r巨噬细胞极化相关分子;进一步生物信息数据分析表明miR-34a-5p与Csf1r的表达呈现负相关性,荧光定量RCR表明miR-34a-5p在小鼠血液中的表达与年龄呈正相关性,双荧光素酶报告基因实验表明Csf1r是miR-34a-5p的一个靶基因;文献数据挖掘发现多种非编码RNA分子通过miR-34a-5p/Csf1r信号轴形成复杂调控网络.结论:...
Here we hypothesized that miR-34a and miR-34b/c may represent mediators of the suppressive effects of aspirin on CRC cells. Indeed, we found, that salicylate, the main metabolite of aspirin, induces the expression ofmiR-34aandmiR-34b/cin a p53-independent manner via activating of AMP-activate...