双荧光素酶报告基因实验表明Csf1r是miR-34a-5p的一个靶基因;文献数据挖掘发现多种非编码RNA分子通过miR-34a-5p/Csf1r信号轴形成复杂调控网络.结论:miR-34a-5p是一个新的急性肺损伤调节因子,通过靶向抑制Csf1r基因表达,可能调控巨噬细胞极化与急性肺损伤的发生发展,本研究为临床急性肺损伤的诊疗提供理论依据与候选...
aspirin suppresses the progression of established CRCs. However, the underlying molecular mechanisms are not completely understood. Here we found that salicylate induces the expression of themiR-34aandmiR-34b/cgenes, which encode tumor suppressive microRNAs...
wounding taxis chemotaxis 10mm 100 T 80 60 T T 40 20 0 MS275 24h T ++ Usc UmiR-194-5p 40 T 35 30 25 20 T 15 10 5 0 T TT T -+ -+ ++ ++ ++ Usc UmiR-194-5p 8 7T 6 5T 4T 3 2T 1TTT T 0 - + - + MS275 ++ ++ GM-CSF + IL-4 + + LPS Usc UmiR-194-5p ...
Chromatin-associated CSF-1R binds to the promoter of proliferation-related genes in breast cancer cells Oncogene, 33 (2014), pp. 4359-4364 CrossrefView in ScopusGoogle Scholar 41 L. Chen, L.Y. Bourguignon Hyaluronan-CD44 interaction promotes c-Jun signaling and miRNA21 expression leading to Bcl...
In the response to RANKL's stimulation, NFATc1 is considered to serve as a master transcription factor, and other regulatory factors such as macrophage colony-stimulating factor (M-CSF), c-Fos, PU.1, and TRAF6 are also known to be activated [8]. It is reported that miRNAs such as miR...
2.4. Bone Resorption Assay Purified human monocytes were seeded at 5 × 104 cells/well on dentine slices (IDS, Gaithersburg, MD, USA) in 96-well plates containing α-MEM with 10% FBS and M-CSF (20 ng/mL) for 72 h. The M-CSF-treated cells were incubated with RANKL and TNF-α (...
Some miRNAs, such as miR-125b, miR-126, miR-21, miR-22, miR-29, miR-210, miR-34a, miR-449a, miR-494, and the miR-200 family, have been found to play a role in the pathogenesis of cellular senescence [18,19]. Regretfully, there have been no reports on the regulation of ...
GCAT genesT A C G GCAT Article A Novel Mechanism of bta-miR-210 in Bovine Early Intramuscular Adipogenesis Ling Ren 1,†, Qian Li 1,†, Xin Hu 1,2, Qiyuan Yang 3, Min Du 4, Yishen Xing 1, Yahui Wang 1, Junya Li 1 and Lupei Zhang 1,* 1 Key Laboratory of Animal Genetics ...