MiR-34a Link to PD-L1 May Mean New Immunotherapy in NSCLCC.G. Evans, PhD
As an upstream regulator of PD-L1, CCL22 and DGKζexpression, miR-34a was identified as an important regulator of immune response in cancer.31,85,86MiR-34a overexpression reversed chemotherapeutic agent-induced PD-L1 expression, reduced PD-L1 specific T cell apoptosis and inhibited Treg recruitmen...
PD-L1 expression. However, it is not known how EBV alters ICs in the context of its preferred host, the B lymphocyte and in derived lymphomas. Here, we found that latency III-expressing Burkitt lymphoma
Tumor suppressor miR-34a targets PD-L1 and functions as a potential immunotherapeutic target in acute myeloid leukemia. Cell Signal. 2015;27(3):443–52. 13. Wang J, Wang H, Liu A, Fang C, Hao J, Wang Z. Lactate dehydrogenase a negatively regulated by miRNAs promotes aerobic glycolysis ...
Epstein-Barr virus-encoded EBNA2 alters immune checkpoint PD-l1 expression by downregulating miR-34a in B-cell lymphomas. Leukemia 2018. [CrossRef] [Pub... Anastasiadou,Eleni,Stroopinsky,... 被引量: 0发表: 0年 The Epstein-Barr Virus Oncogene EBNA1 Suppresses Natural Killer Cell Responses and...
et al. Tumor suppressor miR-34a targets PD-L1 and functions as a potential immunotherapeutic target in acute myeloid leukemia. Cell Signal 27, 443–452 (2015). CAS PubMed Google Scholar Ji, Q., Hao, X., Zhang, M. et al. MicroRNA miR-34 inhibits human pancreatic cancer tumor-...
miR-16-5p通过调控PD-L1表达影响肝星状细胞炎症反应的研究[J].浙江医学,2022,44(19):2049-2055. [5] 江巧丽,朱佳杰,戴蕾,罗灵和,杨珠莹.基于miR-34a/SIRT1轴探讨奥沙拉秦钠治疗溃疡性结肠炎的作用机制[J].浙江医学,2019,41(23):2486-2491. [6] 李玲,李庆玲,刘文春.干预miR-31对哮喘小鼠肺组织TGF-...
目的 探讨微小核糖核酸34a(miR-34a)与程序性细胞死亡受体1(PD-1),程序性细胞死亡配体1(PD-L1)在膀胱癌中的临床意义.方法 选取2019年1月至2022年1月该院收治的45例膀胱癌患者作为研究对象.比较miR-34a,PD-1,PD-L1在膀胱癌中的表达及其与临床病理参数的关系,以及miR-34a表达与PD-1,PD-L1的相关性.结果 不...
本发明涉及一种超声联合靶向PDL1载miR34a微泡的制备方法,具体是将生物素化脂质微泡与链酶亲和素孵育,加入生物素化的PDL1抗体,经孵育后离心得到靶向PDL1微泡.将所得的靶向PDL1微泡和miR34a质粒室温下孵育,再用PBS冲洗,离心,除去未结合在微泡表面的miR34a质粒,得到靶向PDL1载miR34a微泡.本发明将靶向PDL1载miR...
(P<0.05);miR-34a在TNBC细胞中的表达量是癌旁组织中的0.58倍(0.546±0.083 vs 0.940±0.097),差异显著(P<0.05);并且,miR-34a和PD-L1的表达呈负相关性(r=-0.403,P<0.05).结论 PD-L1在TNBC细胞中的表达阳性率高,miR-34a低,且miR-34a与PD-L1的表达呈负相关性,提示在TNBC中,miR-34a可能参与调控PD-L1...