MiR-34a Link to PD-L1 May Mean New Immunotherapy in NSCLCC.G. Evans, PhD
Western blot 结果显示,乳腺癌组织 miR-34a-5p 表达水平明显低于正常组织,IMP3、PD-L1 mRNA 与蛋白表达水平明显高于正常 组织,miR-34a-5p 表达分别与 IMP3 mRNA、PD-L1 mRNA 呈明显负相关(P<0. 05);免疫组化结果显示,乳腺癌组织 IMP3、PD-L1、CD44v6 呈阳性表达,且 IMP3、PD-L1 表达越高,TNM...
他们还证明,hsa_circRNA_047733可能是OSCC中LNM的新生物标志物。从血浆中分离的外泌体表面的循环PD-L1成为头颈鳞状细胞癌(HNSCC)患者疾病和免疫活动的有用指标。OSCC LN1-1细胞除了增强淋巴内皮细胞(LECs)迁移和管状形成的能力外,还比其亲本的OEC-M1细胞表现出更大的淋巴发生和淋巴结转移能力。LEC对富含层蛋白γ2...
有研究 [24] 提出,miR-34 与 PD-L1 在三阴性乳腺癌中的表达呈负相关.PD-L1 在 三阴性乳腺癌中的表达阳性率明显高于癌旁组织 (P < 0.05),而 miR-34a 的表达明显低于癌旁组织 (P < 0.05).据此可以推断,在三阴性乳腺癌中,上调 miR-34a 的表达水平能够降低 PD-L1 的表达, miR-34a 可以看成是三阴性...
(E2F3), cancer stem-like cell phenotype (CD44, NANOG and SOX2), motility (SNAI1, MET and AXIN2) or immune evasion (PD-L1, DGKζ). MiR-34a therefore exerts wide-range effects on cancer progression and metastasis (for overview see references9,10,28,29and an updated database of validated...
目的探讨咳嗽变异性哮喘(CVA)患儿血miR-34a表达水平与免疫失衡状态和炎症反应的关系。方法选取2019年1月至2021年12月中国人民武装警察部队海警总队医院呼吸科收治的CVA患儿92例为研究对象(CVA组),另选取同期在本院健康体检的儿童86名为健康组。采用RT-PCR法检测血miR-34a表达水平,使用全自动血液分析仪检测血嗜酸性粒...
Cancer cells subvert host immune surveillance by altering immune checkpoint (IC) proteins. Some Epstein−Barr virus (EBV)-associated tumors have higher Programmed Cell Death Ligand, PD-L1 expression. However, it is not known how EBV alters ICs in the c
Tumor suppressor miR-34a targets PD-L1 and functions as a potential immunotherapeutic target in acute myeloid leukemia. Cell Signal. 2015;27(3):443–52. 13. Wang J, Wang H, Liu A, Fang C, Hao J, Wang Z. Lactate dehydrogenase a negatively regulated by miRNAs promotes aerobic glycolysis ...
Abstract A16: Epstein-Barr virus encoded EBNA2 alters immune checkpoint PD-L1 expression by downregulating miR-34a in B cell lymphomas Slack. Epstein-Barr virus encoded EBNA2 alters immune checkpoint PD-L1 expression by downregulating miR-34a in B cell lymphomas [abstract]. In: ... A Eleni,S...
In this first-in-human, Phase 1 study of a microRNA-based cancer therapy, the recommended Phase 2 dose (RP2D) of MRX34, a liposomal mimic of microRNA-34a (miR-34a), was determined and evaluated in patients with advanced solid tumours. Adults with various