机制研究发现高糖诱导VSMCs钙化/衰老过程中miR-34c-5p上游的lncRNA-ES3表达上调,并通过海绵吸附miR-34c-5p而促进其下游靶基因Bcl-2 修饰因子 (Bcl-2 modify factor, BMF)表达增加,从而加速VSMCs钙化/衰老。该研究将lncRNAs、miRNAs...
2.5 miR⁃34c、miR⁃29b对SNHL的预测价值miR-34c预测SNHL患者病情严重程度的敏感度80.65%,特异度78.00%,AUC值为0.752;miR-29b预测SNHL患者病情严重程度的敏感度82.64%,特异度76.45%,AUC值为0.763;拟合诊断预测SNHL患者病情严重程度的...
Two human normal nasopharyngeal cell lines (immortalized; NP69 and NP460), as well as the NPC cell line C666-1, were used for miR-34c gain-of-function and loss-of-function experiments. Signaling pathways were assessed using quantitative real-time PCR (qRT-PCR) and Western blot. Cell ...
流行病学研究表明,阿尔茨海默病(AD)与癌症之间存在负相关性,河北医科大学徐顺江教授团队因此关注到肿瘤抑制因子miR-34c的上游信号通路和下游分子机制在AD病理中起着关键作用,在Aging Cell上发表题为Increased miR‐34c mediates synaptic deficits by targeting synaptotagmin 1 through ROS‐JNK‐p53 pathway in Alzheimer...
男性特发性少精症、弱精症精液外泌体miR-34c表达水平变化及临床意义 ·３０ ·中国性科学 ２０２１年９月 第３０卷 第９期 ＣｈｉｎｅｓｅＪｏｕｒｎａｌｏｆＨｕｍａｎＳｅｘｕａｌｉｔｙ， Ｓｅｐｔｅｍｂｅｒ２０２１， Ｖｏｌ．３０，Ｎｏ．９ ［１４］ 王轩久，王艳玲，杨磊，等．西地那非联合曲唑...
这篇研究聚焦猪流行性腹泻病毒(PEDV),发现其感染激活 miR-34c/COX1 轴,导致仔猪小肠上皮细胞线粒体功能障碍和自噬。该研究为 PEDV 致病机制提供新视角,有望为防控该病毒引发的疾病提供潜在靶点。 广告 X 猪流行性腹泻病毒(PEDV)研究背景 猪流行性腹泻病毒(PEDV)是一种在猪群中传播的肠道病原体,主要通过粪口途...
《miR-34c-5p在鼻咽癌转移中的作用和机制研究》是依托中山大学，由柳娜担任项目负责人的青年科学基金项目。中文摘要 远处转移是制约鼻咽癌疗效提高的关键因素。只有鉴定出与鼻咽癌转移相关的因素，系统阐明其作用和机制，才能指导临床甄选出高转移风险患者进行个体化治疗，从而达到提高疗效的目的。我们前期研究发现：①一组...
In this study, we analyzed the expression profile of miR-34c-3p in non-small cell lung cancer (NSCLC) tissues and cell lines, as its participation in some other types of cancer has been shown by previous reports. We found that miR-34c-3p was downregulated both in NSCLC tissues and cell...
Regulation of Myc by miR-34c: A mecha- nism to prevent genomic instability? Cell Cycle. 2010; 9: 2726-30.Cannell IG , Bushell M ( 2010 ) Regulation of Myc by miR-34c: a mechanism to prevent genomic instability? Cell Cycle 9 : 2726 – 2730...