The highest rate of expression reduction was observed in hsa-miR-34c-5p and in oligoasthenoteratospermic patients (P = 0.011, F = 4.01). The results revealed that the frequency of methylation of the promoter region of hsa-miR-34b,c in infertile men was higher than that of fertile men ...
for hsa‑miR‑34b‑5p in non‑obstructive azoospermia: a C a2+/apoptosis pathway cross‑talk Bahareh Maleki 1, Parastoo Modarres 1, Peyman Salehi 2 & Sadeq Vallian 1* MiR-34b-5p has been reported as a non-invasive diagnostic biomarker for ...
three miRNAs of the most upregulated were chosen: miR-320c, miR-200c-3p, and miR-449c-5p. These miRNAs were validated by qPCR and were shown to be differently expressed in COPD patients. ROC analysis showed that these three miRNAs together had an area under the curve of 0.89 in differe...
MiR-34c-5p modulates X-box-binding protein 1 (XBP1) expression during the adaptive phase of the unfolded protein response. FASEB J. 2019, 33, 11541–11554. [Google Scholar] [CrossRef] Zhao, Z.; Lin, C.Y.; Cheng, K. SiRNA- and miRNA-based therapeutics for liver fibrosis. Transl. ...
前期研究中有学者选择mirbase、miranda、targetscan、pictar数据库或预测软件预测hsa-mirna-451靶基因,并对预测的hsa-mirna-451靶基因的基因集合进行功能富集分析和信号转导通路富集分析。研究发现至少3个数据库或预测软件预测到hsa-mirna-451靶基因的靶点18个;功能富集分析预测的结果显示,hsa-mirna-451靶基因主要参与上...
Differential expression of TNFα and hsa-miR-34c in human donor PBMCs following exposure to wild-type (wt) HCT116 or HMGB1 stable knock-down (kd) lysates.Sebnem, Unlu
EIF4A3-induced circTOLLIP promotes the progression of hepatocellular carcinoma via the miR-516a-5p/PBX3/EMT pathway. J. Exp. Clin. Cancer Res. https://doi.org/10.1186/s13046-022-02378-2 (2022). Article PubMed PubMed Central Google Scholar Wang, F. et al. CircNOL10 suppresses breast...
MiR-34c-3p targets CDK1 a synthetic lethality partner of KRAS in non-small cell lung cancer. Cancer Gene Ther. 2021, 28, 413–426. [CrossRef] [PubMed] 35. Sunada, S.; Saito, H.; Zhang, D.; Xu, Z.; Miki, Y. CDK1 inhibitor controls G2/M phase transition and reverses DNA ...
We also evaluated the relationship between hsa-mir-34c and early human embryo development in these 102 sperm samples and obtained negative results. Conclusions: These findings suggest that high hsa-mir-191-5p expression in sperm is associated with early human embryonic quality and that hsa-mir-191...