Additionally, transfection of cells with miR-137 mimics reduced ERRα mRNA stability and increased the chemosensitivity of NPC cells. Furthermore, ERRα knockdown reduced glucose consumption, and lactate and ATP production rates in chemoresistant cells. The aforementioned findings suggested that the miR...
Direct transfection of miR-137 mimics is more effective than DNA demethylation of miR-137 promoter to augment anti-tumor mechanisms of delphinidin in human glioblastoma U87MG and LN18 cells Gene, 573 (2015), pp. 141-152 View PDFView articleView in ScopusGoogle Scholar 54 D. Li, W. Shan,...
MiR-137 is a classic 23-nt microRNA located within a long non-coding host gene,MIR137HG. This transcriptional unit on chromosome 1 is over 62 kb long and is predicted to produce four splice variants ranging from over 2.5 kb to below 1 kb. There is also a 15-bp variable tandem...
For example, delivery of miR- 34 and let-7 mimics inhibited tumor development in mouse models of lung and prostate cancers.119–121 Some other specific miRNAs currently in development as clinical candidates include miR-155, miR-21 and miR-33.122 Although miR-137 also presents as a promising ...
方法采用miR-137寡聚核甘酸(miR-137 mimics)转染LN229细胞;用实时定量PCR(qRT-PCR)检测... 李民,周鹏,张亮,... - 《临床神经外科杂志》 被引量: 0发表: 2018年 MiR-137对人脑胶质瘤细胞株U87细胞增殖和凋亡影响的体外研究 目的 探讨miR-137对胶质瘤细胞株U87细胞增殖和凋亡的影响及相关作用机制.方法 ...
MiR-137 mimics were transfected into HCT116 and LoVo cell to transiently increase the miR-137 expression. The results from cell migration and invasion assays showed that the overexpression of miR-137 significantly inhibited HCT116 and LoVo cell migration and invasion via cell migration and invasion ...
miR-137通过TWIST1调控乳腺癌MDA-MB-231细胞侵袭、迁移及凋亡
目的:探讨咪达唑仑(MID)对胃癌细胞的增殖,凋亡的影响及其作用机制.方法:以胃癌HGC-27细胞为研究对象,采用不同浓度的MID处理,采用细胞增殖/毒性检测试剂盒(CCK-8)检测细胞增殖;流式细胞仪检测细胞的凋亡;实时荧光定量聚合酶链反应(qRT-PCR)检测微小RNA (miR)-137的表达量;miR-137 mimics转染至HGC-27细胞,采用上...
Our observation that upregulating tumor suppressive miR-137 and miR-34a via miRNA mimics restored tumor suppressor activity, with successful inhibition of OC cell viability and invasiveness, provided a rationale to investigate “miRNA replacement therapy for miR-137 and miR-34a”. However, there are ...
the result was quantified by comparing with the internal control U6.c–gDetection of viability of BC cells transfected with miR-137 mimics (5 nM) or negative control (NC) RNA and cultured with 0, 0.5, 1.0, 1.5, and 2.0 µg/ml DOX for 48 h.h–lDetection of viability of BC...