CDC25A overexpression or IL-6 treatment could attenuate inhibiting impact of miR-99a-5p overexpression on epithelial鈥搈esenchymal transition (EMT). These findings suggested that miR-99a-5p may play an anti-tumor role in tumor metastasis by targeting CDC25A/IL6 to hamper EMT process, which ...
Among these, miR-99a-3p has been implicated in the pathogenesis of GC. In the context of our study, we embarked on the comprehensive examination of miR-99a-3p expression in GC cells. Additionally, we sought to establish a correlation between miR-99a-3p expression levels and the overall ...
MiR-7849-3p, miR- 381-3p and miR-505-3p displayed poor results of melting curving analysis; no significant difference was observed in the levels of miR-877-5p, miR-106-5p, miR-335-5p, let-7e-5p, miR-3615, miR-99a-5p, miR-148b-3p and miR- 4433b-3p between LOH patients and ...
MicroRNA miR-145-5p Inhibits Cutaneous Wound Healing by Targeting PDGFD in Diabetic Foot Ulcer Diabetic foot ulcer (DFU) is one major, common and serious chronic complication of diabetes mellitus, which is characterized by high incidence, high risk, ... C Wang,L Huang,J Li,... - 《Biochem...
Based on these results, we focused on seven miRNAs, miR-17, miR-30a-3p, miR-30a-5p, miR- 92a, miR-181a, miR-342–3p and miR-1246, all of which have been reported as oncogenic miRNAs (oncomiRs)22–28. Using quantitative RT-PCR (qRT-PCR), we could validate the differential ...
本实验通过生物信息学分析预测miR-424-4p、miR-99a-5p与miR-26a-5p的靶基因,分析显示miR-26a-5p可通过PTEN/AKT通路调节PD-L1表达。进一步查询TargetScan和miRDB数据库证实PTEN是miR-26a-5p的靶点,并且通过双荧光素酶报告基因检测验证了PTEN是miR-26a-5p的靶点(图3a,P<0.01)。将THP-1巨噬细胞分别转染miR-26a-...
Abbreviations: Con, control; EMT, epithelial-to-mesenchymal transition; HMGN5, high-mobility group nucleosome binding domain 5; miR-NC, miR-488 negative control; qRT-PCR, quantitative real-time polymerase chain reaction; RCC, renal cell carcinoma. 2212 submit your manuscript | www.dovepress.com ...
MiR-99a enhances the radiation sensitivity of non-small cell lung cancer by targeting mTOR. Cell Physiol Biochem. 2018;46(2):471–81.10.1159/000488615Search in Google Scholar PubMed [40] Zhai G, Li G, Xu B, Jia T, Sun Y, Zheng J, et al. miRNA-148b regulates radioresistance in ...
miR-92b targets DAB2IP to promote EMT in bladder cancer migration and invasion. Oncol Rep. 2016;36:1693–701. Article CAS Google Scholar Li Q, Shen K, Zhao Y, Ma C, Liu J, Ma J. MiR-92b inhibitor promoted glioma cell apoptosis via targeting DKK3 and blocking the Wnt/beta-catenin ...
5p miR-518b miR-520g miR-455-5p miR-512-3p miR-517c miR-141 miR-126 miR-19a miR-300-3p miR-210 miR-125a-3p miR-212 miR-193b miR-125a-5p miR-194 miR-522 T24 cells miR-518f miR-150 miR-200a miR-15a miR-99a miR-107 miR-502-3p miR-523 miR-576-3p miR-328 miR-365 ...