The coordination between cellular differentiation and the mesenchymal/stem transition is essential for both embryo development and neoplasia, suggesting a mechanistic link between these two major processes. In this work we show that miR-127, an embryo-expressing lung miRNA, was prominently induced in ...
MicroRNA-200c inhibits the metastasis of non-small cell lung cancer cells by targeting ZEB2, an epithelial-mesenchymal transition regulator. Mol Med Rep 2016; 13: 3349–3355. Article CAS PubMed Google Scholar Yin K, Yin W, Wang Y, Zhou L, Liu Y, Yang G et al. MiR-206 suppresses ...
Takeyama Y, Sato M, Horio M, Hase T, Yoshida K, Yokoyama T, Nakashima H, Hashimoto N, Sekido Y, Gazdar AF, Minna JD, Kondo M, Hasegawa Y (2010) Knockdown of ZEB1, a master epithelial-to- mesenchymal transition (EMT) gene, suppresses anchorage- independent cell growth of lung cancer...
A recent study has shown that sulforaphane attenuates the EGFR signaling pathway in non-small cell lung cancer (NSCLC), suggesting its potential anti-metastatic effects. In this study we assessed the involvement of sulforaphane and miR-616-5p in epithelial-mesenchymal transition (EMT) and NSCLC ...
In the tumor-associated miRNAs, the mechanism of miR-139-5p in cancer initiation and progression drew our attention, because miR-139-5p has been found to perform various biological functions in other types of malignancy, such as bladder, colon, esophageal, liver and lung cancer [14,15,16,17...
Activation of the Erk pathway is required for TGF-beta1-induced EMT in vitro. Neoplasia. 2004;6(5):603–10. Article CAS PubMed PubMed Central Google Scholar Buonato JM, Lazzara MJ. ERK1/2 blockade prevents epithelial-mesenchymal transition in lung cancer cells and promotes their ...
Ma L. Role of miR-10b in breast cancer metastasis. Breast Cancer Res. 2010;12:210. Article PubMed PubMed Central Google Scholar Shi Y, Luo X, Li P, Tan J, Wang X, Xiang T, et al. miR-7-5p suppresses cell proliferation and induces apoptosis of breast cancer cells mainly by targe...
In non-small cell lung cancer, an inhibitory effect of MALAT1 on the miR-124 level and its association with EMT induction and cancer progression have been shown [102]. Inhibitory direct binding of MALAT1 and miR-124 has also been shown for cervical cancer in experiments on cell cultures and...
MiR-150 alleviates EMT and cell invasion of colorectal cancer through targeting Gli1. Eur. Rev. Med. Pharmacol. Sci. 2017, 21, 4853–4859. [Google Scholar] Zhao, Y.J.; Song, X.; Niu, L.; Tang, Y.; Song, X.; Xie, L. Circulating exosomal mir-150-5p and mir-99b-5p as ...
(c) miR-212-5p expression in human normal nasopharyngeal epithelial cells NP69 cells and NPC cell lines (CNE1, 5-8F, C666-1, 6-10B) was detected by qRT-PCR. ***P < 0.001. Table 1 The correlation between miR-212-5p expression and clinicopathological characteristics of NPC patients ...